HLA typing for spontaneous pancreas-kidney transplantation

doi:10.3877/cma.j.issn.1674-3903.2019.04.015

Abstract

Abstract:

Rejection after spontaneous pancreas and kidney transplantation (SPK), especially the antibody-mediated rejection, is the main cause of allografts loss. Human leukocyte antigen (HLA) typing plays a crucial role in defense against the injury to the allograft by immune system of recipients. HLA antigen typing, especially the HLA molecular typing, could help to choose a compatible allograft for transplantation; and it might have a role in preventing and circumventing rejection, predicting the risk of immunogenicity posttransplantation, as well as guiding posttransplant immunosuppression strategies; thus, improving the allograft function. This paper tries to discuss the reseach progress of the function of HLA typing in SPK and clinical application of HLA typing for organ selection in SPK.

Key words: Human leukocyte antigen typing, Spontaneous pancreas and kidney transplantation, Donor specific antibody, Rejection

Jing Liu, Li Li, Shifeng Li. HLA typing for spontaneous pancreas-kidney transplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2019, 13(04): 319-322.

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