Research progress on the role of kupfer cell in liver transplantation

doi:10.3877/cma.j.issn.1674-3903.2022.05.010

Abstract

Abstract:

Liver transplantation is recognized as the most effective treatment for end-stage liver diseases. In addition to excellent surgical skills, postoperative ischemia reperfusion injury (IRI) and rejection are important factors affecting the prognosis, long-term survival and life quality of patients. Kupfer cell (KC) is resident macrophages in the liver, which plays a crucial role in the process of IRI, rejection and immune tolerance after liver transplantation. This review summarizes the current status and progress of the research on the effects of KC on IRI, rejection and induction of immune tolerance after liver transplantation.

Key words: Liver transplantation, Kupffer cell, Ischemia reperfusion injury, Rejection, Immune tolerance

Changjiang Yu, Minjie Zhao, Jianping Gong. Research progress on the role of kupfer cell in liver transplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2022, 16(05): 314-318.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhyzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-3903.2022.05.010

https://zhyzzz.cma-cmc.com.cn/EN/Y2022/V16/I05/314

References 35

1	谢闰鹏，谷明旗，张凤博，等. 肝移植手术技术的现状和展望[J]. 器官移植，2022, 13(1)：105-110.
2	Zhai Y, Busuttil RW, Kupiec-Weglinski JW. Liver ischemia and reperfusion injury: new insights into mechanisms of innate-adaptive immune-mediated tissue inflammation[J]. Am J Transplant, 2011, 11(8)：1563-1569.
3	Zhai Y, Petrowsky H, Hong JC, et al. Ischaemia-reperfusion injury in liver transplantation-from bench to bedside[J]. Nat Rev Gastroenterol Hepatol, 2013, 10(2)：79-89.
4	Wang H, Xi ZF, Deng L, et al. Macrophage polarization and liver ischemia-reperfusion injury[J]. Int J Med Sci, 2021, 18(5): 1104-1113.
5	Tan L, Jiang W, Lu A, et al. miR-155 aggravates liver ischemia/reperfusion injury by suppressing SOCS1 in mice[J]. Transplant Proc, 2018, 50(10)：3831-3839.
6	Ni M, Zhang J, Sosa R, et al. T-cell immunoglobulin and mucin domain-containing protein-4 is critical for kupffer cell homeostatic function in the activation and resolution of liver ischemia reperfusion injury[J]. Hepatology, 2021, 74(4)：2118-2132.
7	Dai JW, Chen QS, Huang WF, et al. Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome[J]. Acta Biochim Biophys Sin (Shanghai), 2021, 53(5)：601-611.
8	Wang ZY, Han S, Chen XJ, et al. Eva1a inhibits NLRP3 activation to reduce liver ischemia-reperfusion injury via inducing autophagy in kupffer cells[J]. Mol Immunol, 2021, 132：82-92.
9	Ye L, He S, Mao X, et al. Effect of hepatic macrophage polarization and apoptosis on liver ischemia and reperfusion injury during liver transplantation[J]. Front Immunol, 2020, 11：1193.
10	Goikoetxea UN, Serrano-MM, Delgado TC, et al. Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals[J]. Hepatology, 2022, 75(3)：550-566.
11	Wang LH, Li J, He S, et al. Resolving the graft ischemia-reperfusion injury during liver transplantation at the single cell resolution[J]. Cell Death Dis, 2021, 12(6)：589.
12	Yang XY, Lu D, Wang R, et al. Single-cell profiling reveals distinct immune phenotypes that contribute to ischaemia-reperfusion injury after steatotic liver transplantation[J]. Cell Prolif, 2021, 54(10)：e13116.
13	Li XF, Wu YK, Zhang WF, et al. Pre-conditioning with tanshinone IIA attenuates the ischemia/reperfusion injury caused by liver grafts via regulation of HMGB1 in rat kupffer cells[J]. Biomed Pharmacother, 2017, 89：1392-1400.
14	Wu Y, Zhang W, Li M, et al. Nobiletin ameliorates ischemia-reperfusion injury by suppressing the function of kupffer cells after liver transplantation in rats[J]. Biomed Pharmacother, 2017, 89：732-741.
15	Liu Y, Zhang WF, Cheng Y, et al. Activation of PPARγ by curcumin protects mice from ischemia/reperfusion injury induced by orthotopic liver transplantation via modulating polarization of kupffer cells[J]. Int Immunopharmacol, 2018, 62：270-276.
16	Cheng MX, Cao D, Chen Y, et al. α-ketoglutarate attenuates ischemia-reperfusion injury of liver graft in rats[J]. Biomed Pharmacother, 2019, 111：1141-1146.
17	Cheng MX, Li JZ, Chen Y, et al. VEGF-C attenuates ischemia reperfusion injury of liver graft in rats[J]. Transpl Immunol, 2019, 54：59-64.
18	Deng MH, Wang JY, Wu H, et al. IL-4 alleviates ischaemia-reperfusion injury by inducing kupffer cells M2 polarization via STAT6-JMJD3 pathway after rat liver transplantation[J]. Biomed Res Int, 2020：2953068.
19	Mohammed AS, Liang Rui, Schultze DP, et al. Glycine protects partial liver grafts from kupffer cell-dependent ischemia-reperfusion injury without negative effect on regeneration[J]. Amino Acids, 2019, 51(6)：903-911.
20	Gassner JMGV, Nösser M, Moosburner S, et al. Improvement of normothermic ex vivo machine perfusion of rat liver grafts by dialysis and kupffer cell inhibition with glycine[J]. Liver Transpl, 2019, 25(2)：275-287.
21	Yue S, Zhou H, Wang X, et al. Prolonged ischemia triggers necrotic depletion of tissue-resident macrophages to facilitate inflammatory immune activation in liver ischemia reperfusion injury[J]. J Immunol, 2017, 198(9)：3588-3595.
22	Ou ZB, Zhong H, Zhang L, et al. Macrophage membrane-coated nanoparticles alleviate hepatic ischemia-reperfusion injury caused by orthotopic liver transplantation by neutralizing endotoxin[J]. Int J Nanomedicine, 2020, 15：4125-4138.
23	Dai QQ, Jiang W, Liu H, et al. Kupffer cell-targeting strategy for the protection of hepatic ischemia/reperfusion injury[J]. Nanotechnology, 2021, 32(26): 10.1088/1361-6528/abde02.
24	Ding W, Duan Y, Qu Z, et al. Acidic microenvironment aggravates the severity of hepatic ischemia/reperfusion injury by modulating M1-polarization through regulating PPAR-γ signal[J]. Front Immunol, 2021, 12：697362.
25	Xue R, Qiu J, Wei S, et al. Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in kupffer cells[J]. Ann Transl Med, 2021, 9(8)：631.
26	Pan GR, Zhao ZF, Tang CY, et al. Soluble fibrinogen-like protein 2 ameliorates acute rejection of liver transplantation in rat via inducing kupffer cells M2 polarization[J]. Cancer Med, 2018, 7(7)：3168-3177.
27	Wu H, Xu X, Li J, et al. TIM4 blockade of KCs combined with exogenous TGFβ injection helps to reverse acute rejection and prolong the survival rate of mice receiving liver allografts[J]. Int J Mol Med, 2018, 42(1)：346-358.
28	Xu XS, Feng ZH, Cao D, et al. SCARF1 promotes M2 polarization of kupffer cells via calcium-dependent PI3K-AKT-STAT3 signalling to improve liver transplantation[J]. Cell Prolif, 2021, 54(4)：e13022.
29	Zhang WK, Cao D, Wang MH, et al. XBP1s repression regulates kupffer cell polarization leading to immune suppressive effects protecting liver allograft in rats[J]. Int Immunopharmacol, 2021, 91：107294.
30	Liu J, Yu Q, Wu W, et al. TLR2 stimulation strengthens intrahepatic myeloid-derived cell-mediated T cell tolerance through inducing kupffer cell expansion and IL-10 production[J]. J Immunol, 2018, 200(7)：2341-2351.
31	徐雪松. GPR37经调控Kupffer细胞M2型极化诱导老龄鼠供肝免疫耐受的机制研究[D]．重庆：重庆医科大学，2021.
32	刘涛，李金政. 库普弗细胞极化状态在肝移植免疫耐受中的作用[J]. 器官移植，2021, 12(6)：687-691.
33	Wang ZB, Wu LQ, Pan BL, et al. Interleukin 33 mediates hepatocyte autophagy and innate immune response in the early phase of acetaminophen-induced acute liver injury[J]. Toxicology, 2021, 456：152788.
34	Hu Y, Yang C, Shen G, et al. Hyperglycemia-triggered sphingosine-1-phosphate and sphingosine-1-phosphate receptor 3 signaling worsens liver ischemia/reperfusion injury by regulating M1/M2 polarization[J]. Liver Transpl, 2019, 25(7)：1074-1090.
35	Yang F, Wang S, Liu Y, et al. IRE1α aggravates ischemia reperfusion injury of fatty liver by regulating phenotypic transformation of kupffer cells[J]. Free Radic Biol Med, 2018, 124：395-407.

[1]	Kunhe Li, Mengjia Kou, Liting Kuang. Risk factors and prediction model of reintubation after liver transplantation [J]. Chinese Archives of General Surgery(Electronic Edition), 2023, 17(05): 366-371.
[2]	Jian Cui, Qing Dai. The relationship between the proportion of Treg cells and anaphylaxis was studied based on anaphylaxis model induced by hepatic cystic echinococcosis [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(04): 427-430.
[3]	Branch of Organ Transplant of Chinese Medical Association, Branch of Organ Transplant Physicians of Chinese Medical Doctor Association, Shanghai Pharmaceutical Profession Association. Expert Consensus on the Use of Mycophenolic Acid in Chinese Liver and Kidney Transplant Recipients (2023 edition) [J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(05): 257-272.
[4]	Wenqing Lu, Xinyi Chen, Xuefei Ren. Investigation on the quality of life after liver transplantation in children with genetic metabolic diseases [J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(05): 287-292.
[5]	Tieyan Fan, Jun Li, Hong Chen. Diagnosis and treatment experience of new onset viral hepatitis E after liver transplantation [J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(05): 293-296.
[6]	Shuo Chen, Feng Chen, Fei Cheng, Jie Xiang. Pancreas infarction after liver transplantation for glycogen storage disease type Ⅰ complicated with pancreatitis: a case report [J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(05): 300-302.
[7]	Penghao Tang, Wu Zhang. Progress in mechanism research about intestinal microecology with perioperative complications of liver transplantation [J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(05): 303-307.
[8]	Committee of Health Management for Organ Transplant Recipient, China Organ Transplantation Development Foundation, Branch of Organ Transplant Physicians of Chinese Medical Doctor Association, Branch of Organ Transplant of Chinese Medical Association, National Center for Healthcare Quality Management in Liver Transplant. Chinese expert consensus on clinical application of inhibitors of mammalian target of rapamycin in liver transplant recipients (2023 edition) [J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(04): 193-204.
[9]	Lina Zhu, Zizhen Yang, Di Zhang, Yong Zhang, Jinzhen Cai, Jianhong Wang. The application value of contrast-enhanced ultrasound in the diagnosis of hepatic artery complications after liver transplantation [J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(04): 240-245.
[10]	Qing Yan, Ying Liu, Feiwen Deng, Huanwei Chen. Effect of microvascular invasion on survival and prognosis of liver transplantation recipients with liver cancer [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 624-629.
[11]	Mei Liao, Hongjun Zhang, Jieyang Jin, Yan Lyu, Jie Ren. Diagnostic value of bedside contrast-enhanced ultrasound for early hepatic artery thrombosis after liver transplantation [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 630-634.
[12]	Binglin Li, Shaocheng Lyu, Fei Pan, Tao Jiang, Hua Fan, Jiantao Kou, Qiang He, Ren Lang. Correlation analysis between pathogenic bacteria of donor liver perfusion fluid and early infection after liver transplantation [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 656-660.
[13]	Lei Lyu, Xiao Feng, Kaiming He, Kaining Zeng, Qing Yang, Haijin Lyu, Huimin Yi, Shuhong Yi, Yang Yang, Binsheng Fu. Value of revised King's score in evaluation of live transplantation timing for children with acute liver failure due to Wilson's disease and literature review [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 661-668.
[14]	Menglong Wang. Significance of biological characteristics in liver transplantation for HCC [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(05): 490-494.
[15]	Ning Li, Yan Liu, Huiqing Lin. Mechanism and prevention of ischemia-reperfusion injury of donor lung transplantation [J]. Chinese Journal of Thoracic Surgery(Electronic Edition), 2023, 10(04): 247-256.

Please choose a citation manager

Content to export