Chinese expert consensus on organ protection of transplantation (2022 edition)

doi:10.3877/cma.j.issn.1674-3903.2022.01.001

Abstract

China Liver Transplant Registry, National Center for Healthcare Quality Management in Liver Transplant, National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, Committee on Transplant Organ Quality Controll, Branch of Organ Transplant Physicians of Chinese Medical Doctor Association, Organ Procurement and Allocation Working Committee of the China Hospital Association, National Trauma Medical Center Organ Protection Committee. Chinese expert consensus on organ protection of transplantation (2022 edition)[J]. Chinese Journal of Transplantation(Electronic Edition), 2022, 16(01): 1-12.

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References 142

1	van Rijn R, Schurink IJ, de Vries Y, et al. Hypothermic machine perfusion in liver transplantation - a randomized trial[J]. N Engl J Med, 2021, 384(15): 1391-1401.
2	Chen Y, Shi J, Xia TC, et al. Preservation solutions for kidney transplantation: history, advances and mechanisms[J]. Cell Transplant, 2019, 28(12): 1472-1489.
3	Mohr A, Brockmann JG, Becker F. HTK-N: modified histidine-tryptophan-ketoglutarate solution-a promising new tool in solid organ preservation[J]. Int J Mol Sci, 2020, 21(18)：6468.
4	Pagano F, Nocella C, Sciarretta S, et al. Cytoprotective and antioxidant effects of steen solution on human lung spheroids and human endothelial cells[J]. Am J Transplant, 2017, 17(7): 1885-1894.
5	Minor T, Paul A, Efferz P, et al. Kidney transplantation after oxygenated machine perfusion preservation with Custodiol-N solution[J]. Transpl Int, 2015, 28(9): 1102-1108.
6	de Vries RJ, Tessier SN, Banik PD, et al. Supercooling extends preservation time of human livers[J]. Nat Biotechnol, 2019, 37(10): 1131-1136.
7	Nasralla D, Coussios CC, Mergental H, et al. A randomized trial of normothermic preservation in liver transplantation[J]. Nature, 2018, 557(7703): 50-56.
8	Eshmuminov D, Becker D, Bautista Borrego L, et al. An integrated perfusion machine preserves injured human livers for 1 week[J]. Nat Biotechnol, 2020, 38(2): 189-198.
9	Jochmans I, Brat A, Davies L, et al. Oxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial[J]. Lancet, 2020, 396(10263): 1653-1662.
10	Warnecke G, Van Raemdonck D, Smith MA, et al. Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study[J]. Lancet Respir Med, 2018, 6(5): 357-367.
11	Husen P, Boffa C, Jochmans I, et al. Oxygenated end-hypothermic machine perfusion in expanded criteria donor kidney transplant: a randomized clinical trial[J]. JAMA Surg, 2021, 156(6): 517-525.
12	Guyatt GH, Oxman AD, Vist GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations[J]. BMJ, 2008, 336(7650)：924-926.
13	Brozek JL, Akl EA, Jaeschke R, et al. Grading quality of evidence and strength of recommendations in clinical practice guidelines: part 2 of 3. The GRADE approach to grading quality of evidence about diagnostic tests and strategies[J]. Allergy, 2009, 64(8): 1109-1116.
14	Antoine C, Jasseron C, Dondero F, et al. Liver transplantation from controlled donors after circulatory death using normothermic regional perfusion: an initial French experience[J]. Liver Transpl, 2020, 26(11): 1516-1521.
15	Rastogi AN, Yadav SK, Soin AS. Organ procurement in the brain dead donors without in vivo cold perfusion: a novel technique[J]. J Clin Exp Hepatol, 2020, 10(5): 462-466.
16	中华医学会器官移植学分会，中华医学会外科学分会移植学组，中国医师协会器官移植医师分会. 中国心脏死亡捐献器官评估与应用专家共识[J/CD]. 中华移植杂志：电子版， 2014, 8(3): 117-122.
17	Lauterio A, Di Sandro S, Gruttadauria S, et al. Donor safety in living donor liver donation: an Italian multicenter survey[J]. Liver Transpl, 2017, 23(2): 184-193.
18	Assalino M, Majno P, Toso C, et al. In situ liver splitting under extracorporeal membrane oxygenation in brain-dead donor[J]. Am J Transplant, 2018, 18(1): 258-261.
19	Agopian VG, Harlander-Locke MP, Markovic D, et al. Evaluation of early allograft function using the liver graft assessment following transplantation risk score model[J]. JAMA Surg, 2018, 153(5): 436-444.
20	Kalisvaart M, Croome KP, Hernandez-Alejandro R, et al. Donor warm ischemia time in DCD liver transplantation-working group report from the ILTS DCD, liver preservation, and machine perfusion consensus conference[J]. Transplantation, 2021, 105(6): 1156-1164.
21	Adam R, Cailliez V, Segev D, et al. A systematic review and meta-analysis of cold in situ perfusion and preservation of the hepatic allograft: working toward a unified approach[J]. Liver Transpl, 2018, 24(8): 1142-1143.
22	Zhou ZJ, Chen GS, Si ZZ, et al. Prognostic factors influencing outcome in adult liver transplantation using hypernatremic organ donation after brain death[J]. Hepatobiliary Pancreat Dis Int, 2020, 19(4): 371-377.
23	中华医学会器官移植学分会. 中国肝移植供肝获取技术规范(2019版) [J/CD]. 中华移植杂志：电子版， 2019, 13(3): 167-170.
24	Corps CL，Ahmed I, McKenzie S, et al. Functional and histological comparison of rat liver preserved in University of Wisconsin solution compared with tissue preserved in a novel solution[J]. Transplant Proc, 2010, 42(9): 3427-3430.
25	Yagi S, Doorschodt BM, Afify M, et al. Improved preservation and microcirculation with POLYSOL after partial liver transplantation in rats[J]. J Surg Res, 2011, 167(2): e375-e383.
26	Hong JC, Yersiz H, Kositamongkol P, et al. Liver transplantation using organ donation after cardiac death: a clinical predictive index for graft failure-free survival[J]. Arch Surg, 2011, 146(9): 1017-1023.
27	Jay C, Ladner D, Wang E, et al. A comprehensive risk assessment of mortality following donation after cardiac death liver transplant - an analysis of the national registry[J]. J Hepatol, 2011, 55(4): 808-813.
28	Abbasi J. Supercooling triples liver preservation time[J]. JAMA, 2019, 322(18): 1756.
29	de Vries RJ, Tessier SN, Banik PD, et al. Subzero non-frozen preservation of human livers in the supercooled state[J]. Nat Protoc, 2020, 15(6): 2024-2040.
30	Kron P, Schlegel A, Mancina L, et al. Hypothermic oxygenated perfusion (HOPE) for fatty liver grafts in rats and humans[J]. J Hepatol, 2018，68(1)：82-91.
31	Rayar M, Maillot B, Bergeat D, et al. A preliminary clinical experience using hypothermic oxygenated machine perfusion for rapid recovery of octogenarian liver grafts[J]. Prog Transplant, 2019, 29(1)：97-98.
32	Cussa D, Patrono D, Catalano G, et al. Use of dual hypothermic oxygenated machine perfusion to recover extended criteria pediatric liver grafts[J]. Liver Transpl, 2020, 26(6): 835-839.
33	van Rijn R, van Leeuwen OB, Matton APM, et al. Hypothermic oxygenated machine perfusion reduces bile duct reperfusion injury after transplantation of donation after circulatory death livers[J]. Liver Transpl, 2018, 24(5): 655-664.
34	Lai Q, Ruberto F, Melandro F, et al. Hypothermic oxygenated perfusion for a steatotic liver graft[J]. Hepatobiliary Pancreat Dis Int, 2020, 19(1): 88-90.
35	MacConmara M, Hanish SI, Hwang CS, et al. Making every liver count: increased transplant yield of donor livers through normothermic machine perfusion[J]. Ann Surg, 2020, 272(3): 397-401.
36	Lembach Jahnsen H, Mergental H, Perera MTPR, et al. Ex-situ liver preservation with machine preservation[J]. Curr Opin Organ Transplant, 2021, 26(2): 121-132.
37	Legeai C, Durand L, Savoye E, et al. Effect of preservation solutions for static cold storage on kidney transplantation outcomes: a national registry study[J]. Am J Transplant, 2020, 20(12): 3426-3442.
38	Tingle SJ, Figueiredo RS, Moir JA, et al. Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation[J]. Cochrane Database Syst Rev, 2019，3(3): CD011671.
39	De Beule J, Fieuws S, Monbaliu D, et al. The effect of IGL-1 preservation solution on outcome after kidney transplantation: a retrospective single-center analysis[J]. Am J Transplant, 2021，21(2): 830-837.
40	Le Meur Y, Badet L, Essig M, et al. First-in-human use of a marine oxygen carrier (M101) for organ preservation: a safety and proof-of-principle study[J]. Am J Transplant, 2020, 20(6): 1729-1738.
41	Hamed M, Logan A, Gruszczyk AV, et al. Mitochondria-targeted antioxidant MitoQ ameliorates ischaemia-reperfusion injury in kidney transplantation models[J]. Br J Surg, 2021, 108(9): 1072-1081.
42	Kox J, Moers C, Monbaliu D, et al. The benefits of hypothermic machine preservation and short cold ischemia times in deceased donor kidneys[J]. Transplantation, 2018, 102(8): 1344-1350.
43	Peters-Sengers H, Houtzager JHE, Idu MM, et al. Impact of cold ischemia time on outcomes of deceased donor kidney transplantation: an analysis of a national registry[J]. Transplant Direct, 2019, 5(5): e448.
44	De Deken J, Kocabayoglu P, Moers C. Hypothermic machine perfusion in kidney transplantation[J]. Curr Opin Organ Transplant, 2016, 21(3): 294-300.
45	Brat A, de Vries KM, van Heurn EWE, et al. Hypothermic machine perfusion as a national standard preservation method for deceased donor kidneys[J]. Transplantation, 2021. [Epub ahead of print]
46	Foucher Y, Fournier MC, Legendre C, et al. Comparison of machine perfusion versus cold storage in kidney transplant recipients from expanded criteria donors: a cohort-based study[J]. Nephrol Dial Transplant, 2020, 35(6): 1043-1070.
47	Ding CG, Tian PX, Ding XM, et al. Beneficial effect of moderately increasing hypothermic machine perfusion pressure on donor after cardiac death renal transplantation[J]. Chin Med J (Engl), 2018, 131(22): 2676-2682.
48	Meister FA, Czigany Z, Rietzler K, et al. Decrease of renal resistance during hypothermic oxygenated machine perfusion is associated with early allograft function in extended criteria donation kidney transplantation[J]. Sci Rep, 2020, 10(1): 17726.
49	Guzzi F, Knight SR, Ploeg RJ, et al. A systematic review to identify whether perfusate biomarkers produced during hypothermic machine perfusion can predict graft outcomes in kidney transplantation[J]. Transpl Int, 2020, 33(6): 590-602.
50	Darius T, Vergauwen M, Smith T, et al. Brief O₂ uploading during continuous hypothermic machine perfusion is simple yet effective oxygenation method to improve initial kidney function in a porcine autotransplant model[J]. Am J Transplant, 2020, 20(8): 2030-2043.
51	Matos ACC, Requiao Moura LR, Borrelli M, et al. Impact of machine perfusion after long static cold storage on delayed graft function incidence and duration and time to hospital discharge[J]. Clin Transplant, 2018, 32(1): e13130.
52	Wszola M, Domagala P, Ostaszewska A, et al. Time of cold storage prior to start of hypothermic machine perfusion and its influence on graft survival[J]. Transplant Proc, 2019, 51(8): 2514-2519.
53	Rogers N, Wyburn K. COMPARE trial: new hope for organ preservation[J]. Lancet, 2020, 396(10263): 1609-1611.
54	DiRito JR, Hosgood SA, Tietjen GT, et al. The future of marginal kidney repair in the context of normothermic machine perfusion[J]. Am J Transplant, 2018, 18(10): 2400-2408.
55	Elliott TR, Nicholson ML, Hosgood SA. Normothermic kidney perfusion: an overview of protocols and strategies[J]. Am J Transplant, 2021, 21(4): 1382-1390.
56	Rijkse E, de Jonge J, Kimenai HJAN, et al. Safety and feasibility of 2 h of normothermic machine perfusion of donor kidneys in the Eurotransplant Senior Program[J]. BJS Open, 2021, 5(1): zraa024.
57	Weissenbacher A, Lo Faro L, Boubriak O, et al. Twenty-four-hour normothermic perfusion of discarded human kidneys with urine recirculation[J]. Am J Transplant, 2019, 19(1): 178-192.
58	Arykbaeva AS, de Vries DK, Doppenberg JB, et al. Metabolic needs of the kidney graft undergoing normothermic machine perfusion[J]. Kidney Int, 2021, 100(2): 301-310.
59	Kaths JM, Cen JY, Chun YM, et al. Continuous normothermic ex vivo kidney perfusion is superior to brief normothermic perfusion following static cold storage in donation after circulatory death pig kidney transplantation[J]. Am J Transplant, 2017, 17(4): 957-969.
60	Kaths JM, Echeverri J, Linares I, et al. Normothermic ex vivo kidney perfusion following static cold storage-brief, intermediate, or prolonged perfusion for optimal renal graft reconditioning？[J]. Am J Transplant, 2017, 17(10): 2580-2590.
61	Hosgood SA, Thompson E, Moore T, et al. Normothermic machine perfusion for the assessment and transplantation of declined human kidneys from donation after circulatory death donors[J]. Br J Surg, 2018, 105(4): 388-394.
62	Kaths JM, Hamar M, Echeverri J, et al. Normothermic ex vivo kidney perfusion for graft quality assessment prior to transplantation[J]. Am J Transplant, 2018, 18(3): 580-589.
63	Urbanellis P, Hamar M, Kaths JM, et al. Normothermic ex vivo kidney perfusion improves early DCD graft function compared with hypothermic machine perfusion and static cold storage[J]. Transplantation, 2020, 104(5): 947-955.
64	Minor T, von Horn C, Gallinat A, et al. First-in-man controlled rewarming and normothermic perfusion with cell-free solution of a kidney prior to transplantation[J]. Am J Transplant, 2020, 20(4): 1192-1195.
65	Juriasingani S, Jackson A, Zhang MY, et al. Evaluating the effects of subnormothermic perfusion with AP39 in a novel blood-free model of ex vivo kidney preservation and reperfusion[J]. Int J Mol Sci, 2021, 22(13)：7180.
66	Thompson ER, Bates L, Ibrahim IK, et al. Novel delivery of cellular therapy to reduce ischemia reperfusion injury in kidney transplantation[J]. Am J Transplant, 2021, 21(4): 1402-1414.
67	Holt RIG, DeVries JH, Hess-Fischl A, et al. The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) [J]. Diabetes Care, 2021, 44(11): 2589-2625.
68	Shyr BS, Shyr BU, Chen SC, et al. A comparative study of pancreas transplantation between type 1 and 2 diabetes mellitus[J]. Hepatobiliary Surg Nutr, 2021, 10(4): 443-453.
69	Kuan KG, Wee MN, Chung WY, et al. Extracorporeal machine perfusion of the pancreas: technical aspects and its clinical implications-a systematic review of experimental models[J]. Transplant Rev (Orlando), 2016, 30(1): 31-47.
70	中华医学会器官移植学分会. 胰腺移植临床技术操作规范[J]. 中华器官移植杂志， 2019, 40(11): 643-659.
71	Eurotransplant. Annual Report 2020[EB/OL]．(2021-07-29)[2022-02-01]. URL
72	Doppenberg JB, Nijhoff MF, Engelse MA, et al. Clinical use of donation after circulatory death pancreas for islet transplantation[J]. Am J Transplant, 2021, 21(9): 3077-3087.
73	Dholakia S, Royston E, Sharples EJ, et al. Preserving and perfusing the allograft pancreas: past, present, and future[J]. Transplant Rev (Orlando), 2018, 32(3): 127-131.
74	Prudhomme T, Renaudin K, Lo Faro ML, et al. Ex situ hypothermic perfusion of nonhuman primate pancreas: a feasibility study[J]. Artif Organs, 2020, 44(7): 736-743.
75	Stewart ZA, Cameron AM, Singer AL, et al. Histidine-tryptophan-ketoglutarate (HTK) is associated with reduced graft survival in pancreas transplantation[J]. Am J Transplant, 2009, 9(1): 217-221.
76	Kuwae K, Miyagi-Shiohira C, Hamada E, et al. Excellent islet yields after 18-h porcine pancreas preservation by ductal injection, pancreas preservation with MK solution, bottle purification, and islet purification using iodixanol with UW solution and iodixanol with MK solution[J]. J Clin Med, 2019, 8(10)：1561.
77	Noguchi H, Levy MF, Kobayashi N, et al. Pancreas preservation by the two-layer method: does it have a beneficial effect compared with simple preservation in University of Wisconsin solution？[J]. Cell Transplant, 2009, 18(5): 497-503.
78	Qin H, Matsumoto S, Klintmalm GB, et al. A meta-analysis for comparison of the two-layer and University of Wisconsin pancreas preservation methods in islet transplantation[J]. Cell Transplant, 2011, 20(7): 1127-1137.
79	Kumar R, Chung WY, Runau F, et al. Ex vivo normothermic porcine pancreas: a physiological model for preservation and transplant study[J]. Int J Surg, 2018, 54(Pt A): 206-215.
80	Leemkuil M, Lier G, Engelse MA, et al. Hypothermic oxygenated machine perfusion of the human donor pancreas[J]. Transplant Direct, 2018, 4(10): e388.
81	Prudhomme T, Kervella D, Ogbemudia AE, et al. Successful pancreas allotransplantations after hypothermic machine perfusion in a novel diabetic porcine model: a controlled study[J]. Transpl Int, 2021, 34(2): 353-364.
82	Doppenberg JB, Leemkuil M, Engelse MA, et al. Hypothermic oxygenated machine perfusion of the human pancreas for clinical islet isolation: a prospective feasibility study[J]. Transpl Int, 2021, 34(8): 1397-1407.
83	Wang H, Gou W, Strange C, et al. Islet harvest in carbon monoxide-saturated medium for chronic pancreatitis patients undergoing islet autotransplantation[J]. Cell Transplant, 2019, 28(1_suppl): 25S-36S.
84	中华医学会器官移植学分会胰腺小肠移植学组. 中国临床胰岛制备技术专家共识[J]. 中华器官移植杂志， 2019, 40(9): 515-518.
85	Iyer KR. Surgical management of short bowel syndrome[J]. JPEN J Parenter Enteral Nutr, 2014, 38(1 Suppl): 53S-59S.
86	Kawai M, Kitade H, Koshiba T, et al. Intestinal ischemia reperfusion and lipopolysaccharide transform a tolerogenic signal into a sensitizing signal and trigger rejection[J]. Transplantation, 2009, 87(10): 1464-1467.
87	Ramisch D, Rumbo C, Echevarria C, et al. Long-term outcomes of intestinal and multivisceral transplantation at a single center in Argentina[J]. Transplant Proc, 2016, 48(2): 457-462.
88	Abu-Elmagd KM, Costa G, Bond GJ, et al. Five hundred intestinal and multivisceral transplantations at a single center: major advances with new challenges[J]. Ann Surg, 2009, 250(4): 567-581.
89	Mangus RS, Tector AJ, Fridell JA, et al. Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution in intestinal and multivisceral transplantation[J]. Transplantation, 2008, 86(2): 298-302.
90	Nickkholgh A, Contin P, Abu-Elmagd K, et al. Intestinal transplantation: review of operative techniques[J]. Clin Transplant, 2013, 27(Suppl 25): 56-65.
91	Oltean M, Joshi M, Herlenius G, et al. Improved intestinal preservation using an intraluminal macromolecular solution: evidence from a rat model[J]. Transplantation, 2010, 89(3): 285-290.
92	Canovai E, Oltean M, Herlenius G, et al. IGL-1 as a preservation solution in intestinal transplantation: a multicenter experience[J]. Transpl Int, 2020, 33(8): 963-965.
93	Tesi RJ, Jaffe BM, McBride V, et al. Histopathologic changes in human small intestine during storage in Viaspan organ preservation solution[J]. Arch Pathol Lab Med, 1997, 121(7): 714-718.
94	Roskott AM, Nieuwenhuijs VB, Dijkstra G, et al. Small bowel preservation for intestinal transplantation: a review[J]. Transpl Int, 2011, 24(2): 107-131.
95	Søfteland JM, Bagge J, Padma AM, et al. Luminal polyethylene glycol solution delays the onset of preservation injury in the human intestine[J]. Am J Transplant, 2021, 21(6): 2220-2230.
96	Chen Z, Kebschull L, Föll DA, et al. A novel histidine-tryptophan-ketoglutarate formulation ameliorates intestinal injury in a cold storage and ex vivo warm oxygenated reperfusion model in rats[J]. Biosci Rep, 2020, 40(5): BSR20191989.
97	Zhu JZ，Castillo EG, Salehi P, et al. A novel technique of hypothermic luminal perfusion for small bowel preservation[J]. Transplantation, 2003, 76(1): 71-76.
98	Muñoz-Abraham AS, Patrón-Lozano R, Narayan RR, et al. Extracorporeal hypothermic perfusion device for intestinal graft preservation to decrease ischemic injury during transportation[J]. J Gastrointest Surg, 2016, 20(2): 313-321.
99	Guo M, Lu C, Li L, et al. Normothermic extracorporeal membrane oxygenation support: improving the function of intestinal grafts obtained from cardiac death donors[J]. Artif Organs, 2020, 44(10): 1098-1106.
100	Hamed MO, Barlow AD, Dolezalova N, et al. Ex vivo normothermic perfusion of isolated segmental porcine bowel: a novel functional model of the small intestine[J]. BJS Open, 2021, 5(2): zrab009.
101	Stehlik J, Kobashigawa J, Hunt SA, et al. Honoring 50 years of clinical heart transplantation in circulation: in-depth state-of-the-art review[J]. Circulation, 2018, 137(1): 71-87.
102	Minasian SM, Galagudza MM, Dmitriev YV, et al. Preservation of the donor heart: from basic science to clinical studies[J]. Interact Cardiovasc Thorac Surg, 2015, 20(4): 510-519.
103	Niederberger P, Farine E, Raillard M, et al. Heart transplantation with donation after circulatory death[J]. Circ Heart Fail, 2019, 12(4): e005517.
104	Mehra MR. Heart transplantation at 50[J]. Lancet, 2017, 390(10111): e43-e45.
105	Messer S, Page A, Colah S, et al. Human heart transplantation from donation after circulatory-determined death donors using normothermic regional perfusion and cold storage[J]. J Heart Lung Transplant, 2018, 37(7): 865-869.
106	Macdonald PS. Heart transplantation from DCD donors: from the bedside to the bench[J]. Transplantation, 2017, 101(8): 1753-1754.
107	Brant SM, Rosenbaum DH, Cobert ML, et al. Effects of antegrade and retrograde machine perfusion preservation on cardiac function after transplantation in canines[J]. Transplant Proc, 2014, 46(5): 1601-1605.
108	Medressova A, Faizov L, Kuanyshbek A, et al. Successful heart transplantation after 17 h ex vivo time using the Organ Care System-3 years follow-up[J]. J Card Surg, 2021, 36(7): 2592-2595.
109	Vincentelli A, Soquet J, Deblauwe D, et al. Organ Care System for high risk transplantation: a new paradigm[J]. J Heart Lung Transplant, 2021, 40(Suppl 4): S198-S198.
110	Ardehali A, Esmailian F, Deng M, et al. Ex-vivo perfusion of donor hearts for human heart transplantation (PROCEED II): a prospective, open-label, multicentre, randomised non-inferiority trial[J]. Lancet, 2015, 385(9987): 2577-2584.
111	Sponga S, Vendramin I, Bortolotti U, et al. Ex vivo donor heart preservation in heart transplantation[J]. J Card Surg, 2021, 36(12): 4836.
112	Jia JJ, Li JH, Xin L, et al. International organ protection symposium: the fusion of engineering and medicine[J]. Hepatobiliary Pancreat Dis Int, 2019, 18(6): 601-602.
113	Bona M, Wyss RK, Arnold M, et al. Cardiac graft assessment in the era of machine perfusion: current and future biomarkers[J]. J Am Heart Assoc, 2021, 10(4): e018966.
114	White CW, Ambrose E, Müller A, et al. Assessment of donor heart viability during ex vivo heart perfusion[J]. Can J Physiol Pharmacol, 2015, 93(10): 893-901.
115	Carter KT, Lirette ST, Baran DA, et al. The effect of cardiac preservation solutions on heart transplant survival[J]. J Surg Res, 2019, 242: 157-165.
116	Ribeiro RV, Ghashghai A, Yu F, et al. Comparison between steen and somah solutions as primary perfusate components for ex vivo heart perfusion[J]. Circulation, 2017, 136(Suppl 1)：S69.
117	Hu CX, Chen WH, He JX, et al. Lung transplantation in China between 2015 and 2018[J]. Chin Med J (Engl), 2019, 132(23): 2783-2789.
118	Whitford H, Kure CE, Henriksen A, et al. A donor PaO₂/FiO₂ < 300 mmHg does not determine graft function or survival after lung transplantation[J]. J Heart Lung Transplant, 2020, 39(1): 53-61.
119	Farr M, Truby LK, Lindower J, et al. Potential for donation after circulatory death heart transplantation in the United States: retrospective analysis of a limited UNOS dataset[J]. Am J Transplant, 2020, 20(2): 525-529.
120	Woolley AE, Singh SK, Goldberg HJ, et al. Heart and lung transplants from HCV-infected donors to uninfected recipients[J]. N Engl J Med, 2019, 380(17): 1606-1617.
121	Buchko MT, Boroumand N, Cheng JC, et al. Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs[J]. Nat Commun, 2020, 11(1): 5765.
122	Copeland H, Hayanga JWA, Neyrinck A, et al. Donor heart and lung procurement: a consensus statement[J]. J Heart Lung Transplant, 2020, 39(6): 501-517.
123	Levvey B, Keshavjee S, Cypel M, et al. Influence of lung donor agonal and warm ischemic times on early mortality: analyses from the ISHLT DCD Lung Transplant Registry[J]. J Heart Lung Transplant, 2019, 38(1): 26-34.
124	Munshi L, Keshavjee S, Cypel M. Donor management and lung preservation for lung transplantation[J]. Lancet Respir Med, 2013, 1(4): 318-328.
125	王振兴，陈静瑜，郑明峰，等. 肺移植供肺获取100例：冷缺血时间>6 h及肺减容对预后的影响[J]. 中国组织工程研究，2012, 16(5)：835-838.
126	Leiva-Juárez MM, Urso A, Arango Tomás E, et al. Extended post-ex vivo lung perfusion cold preservation predicts primary graft dysfunction and mortality: results from a multicentric study[J]. J Heart Lung Transplant, 2020, 39(9): 954-961.
127	Lund LH, Khush KK, Cherikh WS, et al. The Registry of the International Society for Heart and Lung Transplantation: Thirty-fourth Adult Heart Transplantation Report-2017; Focus Theme: Allograft ischemic time[J]. J Heart Lung Transplant, 2017, 36(10): 1037-1046.
128	Marasco SF, Bailey M, McGlade D, et al. Effect of donor preservation solution and survival in lung transplantation[J]. J Heart Lung Transplant, 2011, 30(4): 414-419.
129	Tian D, Wang Y, Shiiya H, et al. Outcomes of marginal donors for lung transplantation after ex vivo lung perfusion: a systematic review and meta-analysis[J]. J Thorac Cardiovasc Surg, 2020, 159(2): 720-730. e6.
130	Loor G, Warnecke G, Villavicencio MA, et al. Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended-criteria donors (EXPAND): a single-arm, pivotal trial[J]. Lancet Respir Med, 2019, 7(11): 975-984.
131	Ozer K. Advances in limb preservation: from replantation to transplantation[J]. J Hand Surg Am, 2020, 45(7): 626-637.e5.
132	Reece E, Ackah R. Hand transplantation: the benefits, risks, outcomes, and future[J]. Tex Heart Inst J, 2019, 46(1): 63-64.
133	Wilks DJ, Clark B, Kay SPJ. The histocompatibility and immunogenetics of hand transplantation[J]. Int J Immunogenet, 2020, 47(1): 24-27.
134	Schneeberger S, Petruzzo P, Morelon E, et al. 20-year follow-up of two cases of bilateral hand transplantation[J]. N Engl J Med, 2020, 383(18): 1791-1792.
135	Carlsen BT, Al-Mufarrej F, Moran SL. Surgical anatomy of hand allotransplantation[J]. Clin Anat, 2013, 26(5): 578-583.
136	裴国献. 异体肢体移植[M]. 北京：人民卫生出版社， 2009.
137	Tatum R, O′Malley TJ, Bodzin AS, et al. Machine perfusion of donor organs for transplantation[J]. Artif Organs, 2021, 45(7): 682-695.
138	Amin KR, Wong JKF, Fildes JE. Strategies to reduce ischemia reperfusion injury in vascularized composite allotransplantation of the limb[J]. J Hand Surg Am, 2017, 42(12): 1019-1024.
139	Gok E, Kubiak CA, Guy E, et al. Effect of static cold storage on skeletal muscle after vascularized composite tissue allotransplantation[J]. J Reconstr Microsurg, 2020, 36(1): 9-15.
140	Haug V, Kollar B, Tasigiorgos S, et al. Hypothermic ex situ perfusion of human limbs with acellular solution for 24 hours[J]. Transplantation, 2020, 104(9): e260-e270.
141	Said SA, Ordeñana CX, Rezaei M, et al. Ex-vivo normothermic limb perfusion with a hemoglobin-based oxygen carrier perfusate[J]. Mil Med, 2020, 185(Suppl 1): S110-S120.
142	Krezdorn N, Macleod F, Tasigiorgos S, et al. Twenty-four-hour ex vivo perfusion with acellular solution enables successful replantation of porcine forelimbs[J]. Plast Reconstr Surg, 2019, 144(4): 608e-618e.

证据级别	定义
Ⅰ	同质随机对照试验(RCT)的系统评价
	单个RCT(可信区间窄)
	全或无病案系列研究
Ⅱ	同质队列研究的系统评价
	单个队列研究(包括低质量RCT，如随访率<80%)
	结果研究，生态学研究
Ⅲ	同质病例对照研究的系统评价
	单个病例对照研究
Ⅳ	病例系列研究(包括低质量队列及病例对照研究)
Ⅴ	基于经验未严格论证的专家意见

证据级别	定义
Ⅰ	同质随机对照试验(RCT)的系统评价
	单个RCT(可信区间窄)
	全或无病案系列研究
Ⅱ	同质队列研究的系统评价
	单个队列研究(包括低质量RCT，如随访率<80%)
	结果研究，生态学研究
Ⅲ	同质病例对照研究的系统评价
	单个病例对照研究
Ⅳ	病例系列研究(包括低质量队列及病例对照研究)
Ⅴ	基于经验未严格论证的专家意见

推荐强度	定义
强	明确显示干预措施利大于弊或弊大于利
弱	不能确定临床决策或干预措施的利弊或无论质量高低的证据均显示利弊相当

推荐强度	定义
强	明确显示干预措施利大于弊或弊大于利
弱	不能确定临床决策或干预措施的利弊或无论质量高低的证据均显示利弊相当

序号	建议	证据级别	推荐强度
1	腹部器官获取及保存过程中应尽量减少冷缺血和热缺血时间	Ⅱ	强
2	目前供肝保存以静态冷保存(SCS)技术为主	Ⅱ	强
3	UW液和HTK液是目前供肝保存最常用的溶液，二者保存效果接近	Ⅱ	强
4	低温携氧机械灌注可减少心脏死亡器官捐献(DCD)肝移植术后非吻合性胆道并发症发生	Ⅰ	强
5	常温机械灌注(NMP)可促进肝移植术后肝功能恢复，改善移植预后	Ⅰ	强
6	机械灌注(MP)可实现供肝保存修复及转运过程中动态监测与评价供肝质量	Ⅱ	强

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