Progress in the treatment of lung ischemia-reperfusion injury by ex vivo lung perfusion at normal temperature

doi:10.3877/cma.j.issn.1674-3903.2024.01.010

Abstract

Abstract:

Lung transplantation has improved the quality of life and prognosis of patients with various end-stage lung illnesses as an efficient therapy. Severe ischemia-reperfusion injury (IRI) in the donor lung might result in primary graft dysfunction, lowering the overall survival probability following transplant.The mechanism behind the incidence of IRI is currently unknown. As a result, it is critical for the success of lung transplantation to investigate the mechanism of IRI and develop innovative methods of IRI therapy and management. A number of research on treatment IRI have been conducted as a strategy for conserving, assessing, and healing marginal lung grafts. This study outlines the main IRI processes and several IRI treatment techniques during ex vivo lung perfusion (EVLP), with the goal of providing a foundation for precise targeted and tailored therapy of lung IRI during EVLP.

Key words: Ischemia-reperfusion injury, Lung transplantation, Primary graft dysfunction, Ex vivo lung perfusion, Donor lung preservation

Zihan Wang, Jin Zhang, Fei Xiao, Chaoyang Liang. Progress in the treatment of lung ischemia-reperfusion injury by ex vivo lung perfusion at normal temperature[J]. Chinese Journal of Transplantation(Electronic Edition), 2024, 18(01): 48-54.

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https://zhyzzz.cma-cmc.com.cn/EN/Y2024/V18/I01/48

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