The research progress of genetically modified pigs in xenotransplantation

doi:10.3877/cma.j.issn.1674-3903.2017.02.013

Abstract

Abstract:

Organ transplantation is the most effective method to treat end-stage organ failure, but the severe shortage of donor organs has become the biggest obstacle for the development of organ transplantation. Recently, the study of xenotransplantation provides potential alternatives to solve the ever increasing shortage of donor organs. The pig is considered as the most suitable xenograft donor because of its physical and physiological similarity with humans. With the development of gene editing technique, the research and application of genetically modified pigs in the field of xenotransplantation have made great progress. In this review, we will discuss the progress of genetically modified pigs in pig-to-primate xenotransplantation.

Key words: Genetically modified pigs, Xenotransplantation, Gene editing

Pengfei Chen, Huirong Nie, Yifan Dai, Zhiming Cai, Lisha Mou. The research progress of genetically modified pigs in xenotransplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2017, 11(02): 119-124.

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References 61

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策　略	基因修饰
补体调节	hCD46^[42]
	hCD55^[47]
	hCD59^[48]
抗凝和凝血调节	hTM^[20]
抗凝和凝血调节	hCD39^[49]
敲除多糖抗原	GTKO^[50]
预防体液免疫反应	H-转移酶基因^[51]
预防体液免疫反应	Neu5Gc KO^[52]
抑制细胞免疫反应	CD152/CTLA4-Ig^[53]
	LEA29YIns^[54]
	CⅡTA-DN^[55]
抗炎症和抗凋亡	HO-1^[56]
抗炎症和抗凋亡	hA20^[57]
多基因修饰	GTKO/hCD55/hCD59/hCD39^[58]

策　略	基因修饰
补体调节	hCD46^[42]
	hCD55^[47]
	hCD59^[48]
抗凝和凝血调节	hTM^[20]
抗凝和凝血调节	hCD39^[49]
敲除多糖抗原	GTKO^[50]
预防体液免疫反应	H-转移酶基因^[51]
预防体液免疫反应	Neu5Gc KO^[52]
抑制细胞免疫反应	CD152/CTLA4-Ig^[53]
	LEA29YIns^[54]
	CⅡTA-DN^[55]
抗炎症和抗凋亡	HO-1^[56]
抗炎症和抗凋亡	hA20^[57]
多基因修饰	GTKO/hCD55/hCD59/hCD39^[58]

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