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Chinese Journal of Transplantation(Electronic Edition) ›› 2018, Vol. 12 ›› Issue (01): 5-8. doi: 10.3877/cma.j.issn.1674-3903.2018.01.002

Special Issue:

• Original Article • Previous Articles     Next Articles

The short-term clinical research of kidney transplantation from donors with brain tumor

Tao Qiu1, Jiangqiao Zhou1,(), Zhongbao Chen1, Xiaoxiong Ma1, Long Zhang1, Jilin Zou1, Yonglian Chen1   

  1. 1. Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan 430060, China
  • Received:2017-11-29 Online:2018-02-25 Published:2018-02-25
  • Contact: Jiangqiao Zhou
  • About author:
    Corresponding author: Zhou Jiangqiao, Email:

Abstract:

Objective

To summarize the short-term effects of kidney transplantation from the donors with brain tumor.

Methods

The clinical data of 27 recipients who got kidney transplantation from donors with brain tumor in department of organ transplantation of Renmin Hospital of Wuhan University from January 2015 to April 2017 were retrospectively analyzed. The immunosuppression induction therapy of the recipients was double standard reagents of basiliximab, and the immunosuppressive regimen after surgery was mycophenolate mofetil, tacrolimus and prednison. All the recipients were regularly followed up after operation, and with blood routine, hepatorenal function, plasma concentrations of tacrolimus test every time. What′s more, the occurrence of rejection reaction, infection, tumor recurrence were monitored and recorded.

Results

All the recipients were followed-up for 6-36 months up to October 2017. Two recipients suffered from delayed graft function 1 week after operation, 1 of them recovered after treatment, and another recipient recieved dialysis treatment again. One recipient got pulmonary infection 4 months after operation, but died of respiratory failure. Two recipients suffered from reject reaction 3 months and 8 months respectively after operation, and all improved after active treatment. All the recipients did not die except 1 recipient with focal segmental glomerulosclerosis and 1 recipient with pulmonary infection after operation. No tumor recurrence was found in any of the recipients.

Conclusions

The renal from the donor with brain tumor recover well in the short term after transplantation.

Key words: Kidney transplantation, Brain tumor, Donor, Tumor recurrence, Reject reaction

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