Allo- and xeno-transplantation of embryonic pancreatic primordia

doi:10.3877/cma.j.issn.1674-3903.2019.03.021

Abstract

Abstract:

Pancreas, islets and embryonic stem cell transplantation have been clinically or experimentally explored for the treatment of diabetes, which have their own advantages and disadvantages. Pancreatic primordia transplantation is a new attempt. Since the pancreatic primordium contains precursor cell clusters of β cells which has high differentiation potential. These β cells have the potential to produce a large amount of insulin. What′s more, pancreatic primordia still has the advantages of avascularity and low immunogenicity. Pancreatic primordia transplantation can control the blood glucose level of immunocompetent animals for a long time. Pig pancreatic primordia xenotransplantation in mesentery of primates can get over the species barrier without using any immunosuppressive agents and induce immune tolerance, which provides a new idea for the treatment of human diabetes.

Key words: Pancreatic primordia, Avascularity, Rejection, Diabetes, Organogenesis, Allotransplantation, Xenotransplantation

Jian Xu, Zhongyang Li, Yahui Sun, Yening Huang, Shusen Zheng. Allo- and xeno-transplantation of embryonic pancreatic primordia[J]. Chinese Journal of Transplantation(Electronic Edition), 2019, 13(03): 255-258.

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