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中华移植杂志(电子版) ›› 2017, Vol. 11 ›› Issue (01) : 44 -49. doi: 10.3877/cma.j.issn.1674-3903.2017.01.011

所属专题: 文献

综述

他克莫司致移植后糖尿病发病机制的研究和治疗进展
李璐1, 陈慧真2, 梁星光3, 伍亚红3, 杨升华3, 黄玉洁4, 黄明珠5,()   
  1. 1. 310003 杭州,浙江大学医学院附属第一医院药学部
    2. 310016 杭州,浙江大学医学院附属邵逸夫医院药学部
    3. 310003 杭州,浙江大学医学院附属第一医院中心实验室
    4. 310003 杭州,浙江大学医学院附属第一医院临床药学研究中心
    5. 310003 杭州,浙江大学医学院附属第一医院药学部;310003 杭州,浙江大学医学院附属第一医院中心实验室
  • 收稿日期:2016-09-08 出版日期:2017-02-25
  • 通信作者: 黄明珠
  • 基金资助:
    国家自然科学基金(81503048)

Research and treatment progress on post-transplantation diabetes mellitus caused by tacrolimus

Lu Li1, Huizhen Chen2, Xingguang Liang3, Yahong Wu3, Shenghua Yang3, Yujie Huang4, Mingzhu Huang5,()   

  1. 1. Department of Pharmacy, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
    2. Department of Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
    3. Central Laboratory, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
    4. Clinical Pharmacy Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
    5. Department of Pharmacy, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Central Laboratory, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
  • Received:2016-09-08 Published:2017-02-25
  • Corresponding author: Mingzhu Huang
  • About author:
    Corresponding author: Huang Mingzhu, Email:
引用本文:

李璐, 陈慧真, 梁星光, 伍亚红, 杨升华, 黄玉洁, 黄明珠. 他克莫司致移植后糖尿病发病机制的研究和治疗进展[J]. 中华移植杂志(电子版), 2017, 11(01): 44-49.

Lu Li, Huizhen Chen, Xingguang Liang, Yahong Wu, Shenghua Yang, Yujie Huang, Mingzhu Huang. Research and treatment progress on post-transplantation diabetes mellitus caused by tacrolimus[J]. Chinese Journal of Transplantation(Electronic Edition), 2017, 11(01): 44-49.

移植后糖尿病(PTDM)是实体器官移植术后最为常见的严重并发症之一,可导致移植术后移植物失功、感染、心血管疾病发生以及急性排斥反应发生,严重影响移植受者生存率与生存质量。随着器官移植的发展,PTDM越来越受到重视。他克莫司作为一种强效免疫抑制剂,目前广泛应用于移植受者,但较易引起PTDM,限制了其在临床的应用。本文就他克莫司致PTDM发病机制研究及治疗进展作一综述。

Post-transplantation diabetes mellitus (PTDM) is one of the most common and severe complications after solid organ transplantation. PTDM is a high risk factor for graft dysfunction, infection, cardiovascular complications and acute graft rejection, which affected survival rate and the quality of life of recipients. Tacrolimus is a powerful kind of immunosuppressant which is widely used on organ recipients. However, tacrolimus is more diabetogenic than other kind of immunosuppressant. Here we summarized the research and treatment progress of tacrolimus on PTDM.

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