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中华移植杂志(电子版) ›› 2019, Vol. 13 ›› Issue (03) : 215 -218. doi: 10.3877/cma.j.issn.1674-3903.2019.03.011

所属专题: 文献

论著

应用供者髂动脉行腹主动脉搭桥重建移植肝动脉的临床分析
李晓航1, 张佳林1,(), 吴刚1, 刘树荣1, 孟一曼1, 杨蕾1, 李柏峰1, 成东华1   
  1. 1. 110001 沈阳,中国医科大学附属第一医院肝胆外科曁器官移植科
  • 收稿日期:2018-11-13 出版日期:2019-08-25
  • 通信作者: 张佳林
  • 基金资助:
    辽宁省重点研发计划指导计划项目(2017225031)

Hepatic artery reconstruction using donor′s iliac artery through abdominal aorta bypass graft in orthotopic liver transplantation

Xiaohang Li1, Jialin Zhang1,(), Gang Wu1, Shurong Liu1, Yiman Meng1, Lei Yang1, Baifeng Li1, Donghua Cheng1   

  1. 1. Department of Hepatobiliary Surgery & Organ Transplantation, the First Hospital, China Medical University, Shenyang 110001, China
  • Received:2018-11-13 Published:2019-08-25
  • Corresponding author: Jialin Zhang
  • About author:
    Corresponding author: Zhang Jialin, Email:
引用本文:

李晓航, 张佳林, 吴刚, 刘树荣, 孟一曼, 杨蕾, 李柏峰, 成东华. 应用供者髂动脉行腹主动脉搭桥重建移植肝动脉的临床分析[J]. 中华移植杂志(电子版), 2019, 13(03): 215-218.

Xiaohang Li, Jialin Zhang, Gang Wu, Shurong Liu, Yiman Meng, Lei Yang, Baifeng Li, Donghua Cheng. Hepatic artery reconstruction using donor′s iliac artery through abdominal aorta bypass graft in orthotopic liver transplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2019, 13(03): 215-218.

目的

探讨应用供者髂动脉行腹主动脉搭桥重建移植肝动脉对肝移植受者预后的影响。

方法

回顾性分析中国医科大学附属第一医院2006年1月至2018年4月应用供者髂动脉行腹主动脉搭桥重建肝动脉的肝移植受者临床资料,观察其术后肝功能恢复情况及肝动脉血栓等并发症的发生情况,分析采用搭桥方式进行移植肝动脉重建的原因。

结果

共纳入8例受者,其中1例存在脾动脉盗血综合征导致肝总动脉供血不足,3例肝总动脉纤细,4例肝总动脉壁薄弱或分层。重建后肝动脉平均血流为(315±178)mL/min。术后2例受者分别因肝脏流出道和胆管吻合口狭窄导致黄疸,其余受者移植肝功能恢复良好。1例受者术后2个月出现肝动脉血栓形成,继发肝脓肿,半年后因多脏器功能衰竭死亡。其余7例受者随访至2018年11月均存活,肝动脉均通畅,无狭窄或血栓形成。

结论

当供、受者常规肝动脉端端吻合无法实施时,应用供者髂动脉行腹主动脉搭桥重建移植肝动脉是一种可行的肝动脉重建方法。

Objective

To discuss the clinical effect of hepatic artery reconstruction using donor′s iliac artery through abdominal aorta bypass graft in orthotopic liver transplantation.

Methods

The clinical data of liver transplantation recipients who got hepatic artery reconstruction using donor′s iliac artery through abdominal aorta bypass graft from January 2006 to April 2018 in the First Hospital, China Medical University, were retrospectively analyzed. The observation indexes included recovery of liver function and occurrence of complication like hepatic artery thrombosis. Trying to find what types of liver transplantation recipients should receive hepatic artery reconstruction.

Results

Eight recipients were incorporated into study, including 1 recipient with common hepatic artery hypoperfusion because of splenic artery steal syndrome, 3 recipients with slim common hepatic artery, and 4 recipients with weak or stratified common hepatic artery wall. The mean blood flow of the reconstructed hepatic artery was (315±178) mL/min. Except for 2 recipients with jaundice due to stenosis of the hepatic outflow tract and bile duct anastomosis, the liver function of other recipients recovered well. One recipient was diagnosed as hepatic artery thrombosis 2 months after transplantation, and then developed liver abscess and died of multiple organ failure half a year later. The rest of the recipients still alive and no hemadostenosis and thrombosis were found up to November 2018.

Conclusions

When conventional anastomosis of donor and recipient hepatic artery can not be performed, using donor′s iliac artery to reconstruct the hepatic artery of recipient through abdominal aorta bypass graft can be considered.

图1 应用供者髂动脉与受者腹主动脉搭桥重建移植肝动脉术后1个月受者肝脏CT血管成像
1
郑树森. 肝移植临床研究的大数据思维与精准化管理[J/CD]. 中华移植杂志:电子版,2019,13(2).
2
Silva MA, Jambulingam PS, Gunson BK, et al. Hepatic artery thrombosis following orthotopic liver transplantation: a 10-year experience from a single centre in the United Kingdom[J]. Liver Transpl, 2006,12(1): 146-151.
3
Miraglia R, Maruzzelli L, Caruso S, et al. Minimally invasive endovascular and biliary treatments of children with acute hepatic artery thrombosis following liver transplantation[J]. Pediatr Radiol, 2014,44(1): 94-102.
4
Piardi T, Lhuaire M, Bruno O, et al. Vascular complications following liver transplantation: A literature review of advances in 2015[J]. World J Hepatol, 2016,8(1): 36-57.
5
Mourad MM, Liossis C, Gunson BK, et al. Etiology and management of hepatic artery thrombosis after adult liver transplantation[J]. Liver Transpl, 2014,20(6): 713-723.
6
Rajakannu M, Awad S, Ciacio O, et al. Intention-to-treat analysis of percutaneous endovascular treatment of hepatic artery stenosis after orthotopic liver transplantation[J]. Liver Transpl, 2016,22(7): 923-933.
7
Yang Y, Zhao JC, Yan LN, et al. Risk factors associated with early and late HAT after adult liver transplantation[J]. World J Gastroenterol, 2014,20(30): 10545-10552.
8
Horton KM, Talamini MA, Fishman EK. Median arcuate ligament syndrome: evaluation with CT angiography[J]. Radiographics, 2005,25(5): 1177-1182.
9
Shimizu S, Onoe T, Ide K, et al. Complex vascular reconstruction using donor′s vessel grafts in orthotopic liver transplantation[J]. Transplant Proc, 2012,44(2): 574-578.
10
Mabrut JY, Abdullah SS, Rode A, et al. Cryopreserved iliac artery allograft for primary arterial revascularization in adult liver transplantation[J]. Clin Transplant, 2012, 26(1): E12-E16.
11
Herrero A, Souche R, Joly E, et al. Early hepatic artery thrombosis after liver transplantation: what is the impact of the arterial reconstruction type?[J]. World J Surg, 2017,41(8): 2101-2110.
12
Del Gaudio M, Grazi GL, Ercolani G, et al. Outcome of hepatic artery reconstruction in liver transplantation with an iliac arterial interposition graft[J]. Clin Transplant, 2005, 19(3): 399-405.
13
Warner P, Fusai G, Glantzounis GK, et al. Risk factors associated with early hepatic artery thrombosis after orthotopic liver transplantation - univariable and multivariable analysis[J]. Transpl Int, 2011,24(4): 401-408.
14
汪根树,许赤,姜楠,等. 肝动脉-腹主动脉架桥重建移植肝肝动脉74例报告[J]. 器官移植,2012,3(6): 312-315.
15
Soliman T, Bodingbauer M, Langer F, et al. The role of complex hepatic artery reconstruction in orthotopic liver transplantation[J]. Liver Transpl, 2003,9(9): 970-975.
16
Stange BJ, Glanemann M, Nuessler NC, et al. Hepatic artery thrombosis after adult liver transplantation[J]. Liver Transpl, 2003,9(6): 612-620.
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