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中华移植杂志(电子版) ›› 2026, Vol. 20 ›› Issue (02) : 127 -131. doi: 10.3877/cma.j.issn.1674-3903.2026.02.010

病例报告

经程序性活检确诊的青少年肾移植受者亚临床排斥反应诊治一例
李怡茹1, 刘杨艳1, 骆静1, 刘李林1, 曹凯1, 吴黄婕1, 方奕1, 顾民2, 曹红娣1,()   
  1. 1210003 南京,南京医科大学第二附属医院肾脏病中心
    2210003 南京,南京医科大学第二附属医院泌尿疾病中心
  • 收稿日期:2025-08-22 出版日期:2026-04-25
  • 通信作者: 曹红娣
  • 基金资助:
    江苏省科技计划专项资金(重点研发计划社会发展)项目(BE2023784)

A case of subclinical rejection diagnosed by protocol biopsy in an adolescent kidney transplant recipient

Yiru Li1, Yangyan Liu1, Jing Luo1, Lilin Liu1, Kai Cao1, Huangjie Wu1, Yi Fang1, Min Gu2, Hongdi Cao1,()   

  1. 1Department of Nephrology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210003, China
    2Department of Urology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210003, China
  • Received:2025-08-22 Published:2026-04-25
  • Corresponding author: Hongdi Cao
引用本文:

李怡茹, 刘杨艳, 骆静, 刘李林, 曹凯, 吴黄婕, 方奕, 顾民, 曹红娣. 经程序性活检确诊的青少年肾移植受者亚临床排斥反应诊治一例[J/OL]. 中华移植杂志(电子版), 2026, 20(02): 127-131.

Yiru Li, Yangyan Liu, Jing Luo, Lilin Liu, Kai Cao, Huangjie Wu, Yi Fang, Min Gu, Hongdi Cao. A case of subclinical rejection diagnosed by protocol biopsy in an adolescent kidney transplant recipient[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2026, 20(02): 127-131.

图1 亚临床排斥反应青少年肾移植受者术后3个月移植肾活检病理图像注:a.IgA免疫荧光(×400); b.C4d免疫荧光(×400); c.HE(×400); d.电镜,标尺=5 μm; e.PAS(×400); f.PASM-Masson(×400); g.Masson(×200); h.电镜,标尺=2 μm
图2 亚临床排斥反应青少年肾移植受者术后3个月第1次PB前后血清肌酐变化注:PB.程序性活检
图3 亚临床排斥反应青少年肾移植受者术后11个月移植肾活检病理图像注:a.IgG免疫荧光(×400); b.C4d免疫荧光(×400); c.HE(×400); d.电镜,标尺=2 μm; e.PAS(×400); f.PASM-Masson(×400); g.Masson(×200); h.电镜,标尺=2 μm
图4 亚临床排斥反应青少年肾移植受者术后11个月第2次PB前后血清肌酐变化注:PB.程序性活检
表1 亚临床排斥反应青少年肾移植受者术后11个月第2次PB前后新生DSA荧光值变化
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