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中华移植杂志(电子版) ›› 2024, Vol. 18 ›› Issue (01) : 60 -64. doi: 10.3877/cma.j.issn.1674-3903.2024.01.012

综述

非HLA抗体检测方法研究进展
尚丽红1, 武小桐2, 李宁2, 石韶华2, 王志华1, 朱琳茹1, 周华2,()   
  1. 1. 030012 太原,山西省第二人民医院肾移植中心实验室
    2. 030012 太原,山西省第二人民医院肾移植中心
  • 收稿日期:2023-08-07 出版日期:2024-02-25
  • 通信作者: 周华
  • 基金资助:
    山西省卫生健康委员会"四个一批"科技兴医创新计划重点攻关专项资助项目(2021XM24)

Testing methods of non-human leukocyte antigen antibodies

Lihong Shang1, Xiaotong Wu2, Ning Li2, Shaohua Shi2, Zhihua Wang1, Linru Zhu1, Hua Zhou2,()   

  1. 1. Laboratory of Kidney Transplantation Center, Shangxi Second People′s Hospital, Taiyuan 030012, China
    2. Kidney Transplantation Center, Shangxi Second People′s Hospital, Taiyuan 030012, China
  • Received:2023-08-07 Published:2024-02-25
  • Corresponding author: Hua Zhou
引用本文:

尚丽红, 武小桐, 李宁, 石韶华, 王志华, 朱琳茹, 周华. 非HLA抗体检测方法研究进展[J]. 中华移植杂志(电子版), 2024, 18(01): 60-64.

Lihong Shang, Xiaotong Wu, Ning Li, Shaohua Shi, Zhihua Wang, Linru Zhu, Hua Zhou. Testing methods of non-human leukocyte antigen antibodies[J]. Chinese Journal of Transplantation(Electronic Edition), 2024, 18(01): 60-64.

HLA抗体一直是器官移植抗体介导排斥反应(AMR)预防和治疗的焦点,然而来自临床和基础研究的证据表明,非HLA抗体也参与AMR或AMR样组织学损伤。已有多种检测非HLA抗体的方法,可靠和灵敏的检测方法有助于推动非HLA抗体检测在器官移植中的应用,改善临床结局。本文就非HLA抗体检测方法的研究进展进行综述。

Human leukocyte antigen (HLA) antibodies have been the focus in the prevention and treatment of antibody-mediated rejection (AMR) in organ transplantation. However, evidence from the clinic and basic studies has shown that non-HLA antibodies are associated with AMR or AMR like histologic lesions. There have been many methods to test non-HLA antibodies. Reliable and sensitive testing methods can help promote the application of non-HLA antibody detection in organ transplantation and improve clinical outcomes. This article review the research progress on testing methods of non-HLA antibodies.

表1 非HLA抗体检测技术性能比较[16]
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23
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