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中华移植杂志(电子版) ›› 2026, Vol. 20 ›› Issue (02) : 132 -136. doi: 10.3877/cma.j.issn.1674-3903.2026.02.011

综述

NK细胞生物学功能及在移植免疫中的作用
苏彬1, 徐媛1,2,3,(), 李海洋2,3, 侯霜1   
  1. 1550004 贵阳,贵州医科大学临床医学院
    2550004 贵阳,贵州医科大学附属医院器官移植科
    3550004 贵阳,贵州省器官移植中心
  • 收稿日期:2025-08-04 出版日期:2026-04-25
  • 通信作者: 徐媛
  • 基金资助:
    贵州省卫生健康委科学技术基金项目(gzwkj2023-164); 贵州医科大学附属医院教学研究一般项目(JXYJY-2025-034)

The biological functions of NK cells and their roles in transplant immunology

Bin Su1, Yuan Xu1,2,3,(), Haiyang Li2,3, Shuang Hou1   

  1. 1Department of Clinical Medicine, Guizhou Medical University, Guiyang 550004, China
    2Department of Organ Transplantation, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
    3Guizhou Provincial Organ Transplantation Center, Guiyang 550004, China
  • Received:2025-08-04 Published:2026-04-25
  • Corresponding author: Yuan Xu
引用本文:

苏彬, 徐媛, 李海洋, 侯霜. NK细胞生物学功能及在移植免疫中的作用[J/OL]. 中华移植杂志(电子版), 2026, 20(02): 132-136.

Bin Su, Yuan Xu, Haiyang Li, Shuang Hou. The biological functions of NK cells and their roles in transplant immunology[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2026, 20(02): 132-136.

NK细胞作为先天免疫系统的重要组成部分,在人体免疫防御中发挥重要作用。对于器官移植受者,免疫诱导药物及免疫抑制剂可能对NK细胞功能和作用产生影响。在器官移植受者预防和感染治疗的过程中,理解NK细胞的作用及使用免疫抑制剂对其潜在影响至关重要。本文综述NK细胞在器官移植中的作用及免疫抑制治疗对其功能的影响,期望为深入研究NK细胞抗感染和免疫信号传递功能提供参考。

As a key component of the innate immune system, natural killer (NK) cells play a central role in human immune defense, and immunomodulatory agents and immunosuppressive regimens administered to organ transplant recipients may significantly affect their functions and biological effects. Clarifying the dual roles of NK cells and the potential impact of immunosuppressive therapies on their functions is particularly critical for infection prevention and management in this patient population. This review comprehensively explores the multifaceted involvement of NK cells in transplantation immunology, evaluates the effects of immunosuppression on NK cell activity, and provides valuable references for future studies focusing on the anti-infective capabilities of NK cells and their roles in immune signaling pathways in the context of transplantation medicine.

图1 NK细胞介导排斥反应的核心机制及药物干预靶点注:TCMR.T细胞介导排斥反应;AMR.抗体介导排斥反应;DSA.供者特异性抗体;ADCC.抗体依赖细胞介导的细胞毒作用;HLA class I.人类白细胞抗原Ⅰ类分子;mTOR.哺乳动物雷帕霉素靶蛋白;NKG2A.NK细胞受体2A; NKG2D.NK细胞受体2D; NCR.天然细胞毒性受体;CD16.Fcγ受体Ⅲa
表1 不同免疫抑制剂对NK细胞功能的影响
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