C4d and donor specific antibody in the application research of antibody-mediated rejection

doi:10.3877/cma.j.issn.1674-3903.2017.01.013

Abstract

Abstract:

Antibody-mediated rejection (AMR) has become a main reason in graft loss. The detection of C4d deposition in peritubular capillarie (PTC) is a valuable marker of humoral activity in the renal allograft. C4d positivity alone is nondiagnostic for antibody-mediated rejection. Presence of circulating HLA donor-specific antibody (DSA), histologic features, and/or graft dysfunction must be considered in the context of the clinical scenario. C4d positivity and DSA, particularly complement fixing, are associated with decreased allograft survival, particularly when detected in the setting of graft dysfunction.

Key words: Kidney transplantation, Antibody-mediated rejection, Human leukocyte antigens, Donor-specific antibody, C4d

Peng Hou, Shuming Ji. C4d and donor specific antibody in the application research of antibody-mediated rejection[J]. Chinese Journal of Transplantation(Electronic Edition), 2017, 11(01): 54-58.

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