Neuropilin 1 and its role in transplantation tolerance

doi:10.3877/cma.j.issn.1674-3903.2017.01.012

Abstract

Abstract:

Once as a receptor on neurons, neuropilin 1 (Nrp1) is recently found to play a role in establishing immunological synapse and regulating immune response. Although Foxp3 had been well accepted as the marker of T regulatory cell (Treg), Nrp1 might serve as another reliable marker to distinguish conventional T cells from Treg. Moreover, Nrp1 has also been identified to have the potential to differentiate natural T regulatory cell from inducible T regulatory cell. Here we reviewed the structure and ligands of Nrp1 and its function in transplantation immunity.

Key words: Neuropilin 1, T regulatory cell, Immune tolerance, Immunological synapse

Dawei Zhang, Ming Cai, Kang Wu. Neuropilin 1 and its role in transplantation tolerance[J]. Chinese Journal of Transplantation(Electronic Edition), 2017, 11(01): 50-53.

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URL: https://zhyzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-3903.2017.01.012

https://zhyzzz.cma-cmc.com.cn/EN/Y2017/V11/I01/50

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结构域	配体
Nrp1 a1/a2	SEMA 3A/4A/3C、HGFR
Nrp1 b1/b2?	TGF-β、TGF-β RIRⅠ/Ⅱ/Ⅲ、VEGF 165/145、VEGF D1/2、PDGFR-ɑ、PIGF

结构域	配体
Nrp1 a1/a2	SEMA 3A/4A/3C、HGFR
Nrp1 b1/b2?	TGF-β、TGF-β RIRⅠ/Ⅱ/Ⅲ、VEGF 165/145、VEGF D1/2、PDGFR-ɑ、PIGF

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