Advancing extracorporeal organ perfusion technology and improving the utilization and quality of donor organs

doi:10.3877/cma.j.issn.1674-3903.2020.02.005

Abstract

Abstract:

Organ transplantation is the only effective treatment for end-stage diseases, and the scarcity of donor organ seriously hinders the development of organ transplantation. Increasing the utilization rate of marginal organs can partially alleviate the shortage of organs. With the continuous development of organ preservation technology, machine perfusion has gradually become an crucial research direction to improve the quality of donor organs. Machine perfusion is expected to be superior organ preservation technology than static cold storage and improves preservation environment and quality assessment system of the isolated donor organ, repairs marginal donor organs and improves organ utilization. We review the research progress of machine perfusion technology and the future development, through the fusion of medicine and engineering, the development of machine perfusion technology will improve the quality and utilization rate of donor organs.

Key words: Organ donation, Ischemia reperfusion injury, Static cold storage, Machine perfusion, Marginal donor

Jianhui Li, Yinbiao Qiao, Junjun Jia, Wenshi Jiang, Haiyang Xie, Lin Zhou, Shusen Zheng. Advancing extracorporeal organ perfusion technology and improving the utilization and quality of donor organs[J]. Chinese Journal of Transplantation(Electronic Edition), 2020, 14(02): 83-86.

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