Research progress of cell senescence in transplantation therapy

doi:10.3877/cma.j.issn.1674-3903.2022.06.011

Abstract

Abstract:

Cell senescence is a stable state of cell cycle arrest when cells are stimulated by stress, which is involved in the aging of the body and the occurrence and development of many chronic diseases. More and more studies have shown that senescent cells have a negative effect on local microenvironment and organ function, which will affect the efficacy of organ transplantation from elderly donors and elderly recipients. Therefore, there is a close relationship between cellular senescence and the efficacy of transplantation. The elimination of senescent cells or the use of anti-senescent compounds is expected to be a new therapy to improve the efficacy of transplantation. This article reviews the effect of cell senescence on the therapeutic effect of transplantation and the latest progress in removing senescent cells as a new therapy to improve the therapeutic effect, so as to lay a foundation for understanding the relationship between cellular senescence and the therapeutic effect of transplantation, and further improve the success rate and prognosis of transplantation.

Key words: Transplantation, Cell senescence, Anti-aging

Huantong Zhang, Han Zhou, Xin Shen, Xingchen Lin, Yiyi Sun, Yi Zhou, Dayong Zhang. Research progress of cell senescence in transplantation therapy[J]. Chinese Journal of Transplantation(Electronic Edition), 2022, 16(06): 379-383.

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https://zhyzzz.cma-cmc.com.cn/EN/Y2022/V16/I06/379

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