Lung transplantation has become an important therapy for patients with end-stage benign lung disease. With the progress of surgical technique, perioperative mananment and immunosuppressive therapy, surival rate in early stage after transplant have significantly improved, while long-term surival rate has not changed much. Obliterative bronchiolitis (OB) is the major limitation to long-term surival after lung transplatation. Ivestigation basing on animal models is indispensable to understand the underlying pathological mechanisms and to develop novel preventive and therapetic stragies for OB. So far, many animal models have been developed to study OB. This article reviews the strengths and drawbacks of those animal models, hoping to help researchers in chooseing the appropriate model for their intrended research.