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中华移植杂志(电子版)

中华移植杂志(电子版) ›› 2022, Vol. 16 ›› Issue (02) : 108 -113. doi: 10.3877/cma.j.issn.1674-3903.2022.02.010

综述

肝移植受者健康相关生命质量和依从性的研究进展
何江娟1, 耿磊2, 王卓轶3, 郑树森4,†()   
  1. 1. 310003　杭州，浙江大学医学院附属第一医院感染管理部
    2. 310003　杭州，浙江大学医学院附属第一医院肝胆胰外科
    3. 310022　杭州，树兰（杭州）医院肝胆胰外科及肝移植科
    4. 310022　杭州，树兰（杭州）医院肝胆胰外科及肝移植科；310003　杭州，浙江大学医学院附属第一医院卫生部多器官联合移植重点实验室
  • 收稿日期:2022-03-06 出版日期:2022-04-25
  • 通信作者: 郑树森
  • 基金资助:
    浙江省医药卫生科技项目(2018266923)

Research progress on health-related quality of life and compliance in liver transplant recipients

Jiangjuan He1, Lei Geng2, Zhuoyi Wang3, Shusen Zheng4,†()   

  1. 1. Department of Infection Management, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    2. Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    3. Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Hangzhou 310022, China
    4. Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Hangzhou 310022, China; NHC Key Laboratory of Combined Multi-Organ Transplantation, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
  • Received:2022-03-06 Published:2022-04-25
  • Corresponding author: Shusen Zheng
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何江娟, 耿磊, 王卓轶, 郑树森. 肝移植受者健康相关生命质量和依从性的研究进展[J]. 中华移植杂志(电子版), 2022, 16(02): 108-113.

Jiangjuan He, Lei Geng, Zhuoyi Wang, Shusen Zheng. Research progress on health-related quality of life and compliance in liver transplant recipients[J]. Chinese Journal of Transplantation(Electronic Edition), 2022, 16(02): 108-113.

肝移植是终末期良性肝病和肝肿瘤的有效治疗手段。健康相关生命质量(HR-QOL)反映受者术后主观感觉、回归家庭和社会的能力，已成为国内外公认的肝移植疗效评价指标。依从性指个人行为(服药、饮食和生活方式改变)与医疗指导、建议的一致程度。肝移植受者依从性与其术后HR-QOL关系密切。本文从肝移植受者HR-QOL和依从性两个方面进行综述，以期为肝移植医疗团队制订相关干预策略提供参考。

关键词: 肝移植, 健康相关生命质量, 依从性

Liver transplantation is an effective treatment for end-stage benign liver diseases and liver tumors. Health-related quality of life (HR-QOL) reflects the recipient′s postoperative subjective feeling, ability to return to family and society, and has become a recognized index for evaluating the efficacy of liver transplantation at home and abroad. Adherence refers to the degree to which an individual′s behavior (medication, diet, and lifestyle changes) is consistent with medical guidance and recommendations. The compliance of liver transplant recipients is closely related to their postoperative HR-QOL. This article reviews the HR-QOL and compliance of liver transplant recipients, in order to provide reference for liver transplant medical teams to formulate relevant intervention strategies.

Key words: Liver Transplantation, Health-related quality of life, Compliance
1
郑树森. 中国肝移植的发展之路[J/CD]. 中华移植杂志：电子版，2019，13(4)：259-261.
2
郑树森，俞军，张武. 肝移植在中国的发展现状[J]. 临床肝胆病杂志，2014，30(1)：2-4.
3
徐骁，张文会，刘治坤. 重视肝移植受者长期管理[J]. 中华器官移杂志，2021，42(3)：129-130.
4
Burra P, Ferrarese A, Feltrin G. Quality of life and adherence in liver transplant recipients[J]. Minerva Gastroenterol Dietol, 2018，64(2)：180-186.
5
Haraldstad K, Wahl A, Andenæs R, et al. A systematic review of quality of life research in medicine and health sciences[J]. Qual Life Res, 2019, 28(10)：2641-2650.
6
WHO. Adherence to long-term therapies: evidence from action[EB/OL]. (2016-08-13)[2022-03-01].

URL    
7
Gorevski E, Succop P, Sachdeva J, et al. Is there an association between immunosuppressant therapy medication adherence and depression, quality of life, and personality traits in the kidney and liver transplant population？[J]. Patient Prefer Adherence, 2013，7：301-307.
8
Jay CL, Butt Z, Ladner DP, et al. A review of quality of life instruments used in liver transplantation[J]. J Hepatol，2009, 51(5)：949-959.
9
Saab S, Ng V, Landaverde C, et al. Development of a disease-specific questionnaire to measure health-related quality of life in liver transplant recipients[J]. Liver Transpl, 2011, 17(5)：567-579.
10
Ng V, Nicholas D, Dhawan A, et al. Development and validation of the pediatric liver transplantation quality of life: a disease-specific quality of life measure for pediatric liver transplant recipients[J]. J Pediatr, 2014，165(3)：547-555.e7.
11
Yang LS, Shan LL, Saxena A, et al. Liver transplantation: a systematic review of long-term quality of life[J]. Liver Int, 2014，34(9)：1298-1313.
12
Waclawski ER, Noone P. Systematic review: impact of liver transplantation on employment[J]. Occup Med (Lond), 2018, 68(2)：88-95.
13
Sullivan KM, Radosevich DM, Lake JR. Health-related quality of life: two decades after liver transplantation[J]. Liver Transpl, 2014, 20(6)：649-654.
14
张利姗，叶海丹，廖昌贵. 肝移植受者生存质量现状及影响因素分析[J/CD]. 中华移植杂志：电子版，2019，13(2)：127-130.
15
Parmar A, Vandriel SM, Ng VL. Health-related quality of life after pediatric liver transplantation: a systematic review[J]. Liver Transpl, 2017, 23(3)：361-374.
16
Miserachs M, Parmar A, Bakula A, et al. Health-related quality of life in pre-adolescent liver transplant recipients with biliary atresia: a cross-sectional study[J]. Clin Res Hepatol Gastroenterol, 2019，43(4)：427-435.
17
McLean KA, Drake TM, Sgrò A, et al. The effect of liver transplantation on patient-centred outcomes: a propensity-score matched analysis[J]. Transpl Int, 2019, 32(8)：808-819.
18
陈潇，张玉侠，俞静娴，等. 肝移植受者症状群及其影响因素的研究[J]. 中华护理杂志，2019，54(8)：1130-1135.
19
Lai JC, Segev DL, McCulloch CE, et al. Physical frailty after liver transplantation[J]. Am J Transplant, 2018，18(8)：1986-1994.
20
Togashi J, Sugawara Y, Akamatsu N, et al. Quality of life after adult living donor liver transplantation: a longitudinal prospective follow-up study[J]. Hepatol Res, 2013，43(10)：1052-1063.
21
Benzing C, Krezdorn N, Hinz A, et al. Mental status in patients before and after liver transplantation[J]．Ann Transplant, 2015, 20(17)：683-693.
22
杜春燕，吴丝丝，张淑萍，等. 肝移植受者疲乏状况与焦虑抑郁情绪的相关性研究[J]. 护理管理杂志，2017，17(10)：713-716.
23
Zimbrean PC, Gan G, Deng Y, et al. Body image in liver transplantation recipients[J]. Liver Transpl, 2019，25(5)：712-723.
24
Annema C, Drent G, Roodbol PF, et al. A prospective cohort study on posttraumatic stress disorder in liver transplantation recipients before and after transplantation: prevalence, symptom occurrence, and intrusive memories[J]. J Psychosom Res, 2017, 95：88-93.
25
叶小舟，卞晨阳，蒋继贫，等. 肝移植和肾移植受者生存质量的调查分析[J]. 中华器官移植杂志，2017，38(4)：218-224.
26
何嫦娥，张玉梅. 不同文化程度对宫颈癌病人生存质量的影响[J]. 江苏医药，2015，4(16)：1984-1985.
27
叶海丹，张利姗，罗新春. 居家肝移植受者睡眠质量现状及其影响因素分析[J/CD]. 中华移植杂志：电子版，2021，15(3)：152-155.
28
林健文，韩明，王小平，等. 公民身后器官捐献肝移植术后早期细菌和真菌感染并发症的临床特点与危险因素分析[J/CD]. 中华普通外科学文献：电子版，2016，10(5)：354-358.
29
Croome KP, Lee DD, Perry DK, et al. Comparison of longterm outcomes and quality of life in recipients of donation after cardiac death liver grafts with a propensity-matched cohort[J]. Liver Transpl, 2017，23(3)：342-351.
30
卫强. 活体肝移植与心脏死亡器官捐献肝移植术后急性排斥反应及预后研究[D]. 杭州：浙江大学，2017.
31
Aberg F, Gissler M, Karlsen TH, et al. Differences in longterm survival among liver transplant recipients and the general population: a population-based Nordic study[J]. Hepatology, 2015, 61(2)：668-677.
32
徐玲，孔悦，彭山玲，等. 肝移植受者生活质量与医学应对方式、领悟社会支持相关性研究[J]. 齐鲁护理杂志，2021，27(5)：1-4.
33
Muller X, Marcon F, Sapisochin G, et al. Defining benchmarks in liver transplantation: a multicenter outcome analysis determining best achievable results[J]. Ann Surg, 2018, 267(3)：419-425.
34
Guirguis RN, Nashaat EH, Yassin AE, et al. Impact of biliary complications on quality of life in live-donor liver transplant recipients[J]. World J Hepatol, 2021，13(10)：1405-1416.
35
Onghena L, Develtere W, Poppe C, et al. Quality of life after liver transplantation: state of the art[J]. World J Hepatol, 2016，8(18)：749-756.
36
Zaydfudim V, Feurer ID, Landman MP, et al. Reduction in corticosteroids is associated with better health-related quality of life after liver transplantation[J]. J Am Coll Surg, 2012，214(2)：164-173.
37
陆晔峰，何康，高磊青. 儿童肝移植受者术后五年生存和睡眠质量调查研究[J/CD]. 中华移植杂志：电子版，2018，12(4)：161-164.
38
盛俊，周利平，薛冰，等. 原位肝移植受者术后症状群与症状困扰现状及其影响因素[J]. 护理研究，2020，34(7)：1170-1175.
39
尚雅彬，滕沙，林晓鸿，等. 271例肝移植术后患者生活质量的调查分析[J]. 护理学报，2016, 23(23)：1-5.
40
唐艳，刘洋，王紫娟，等. 个体化干预模式在儿童肝移植受者术后随访中的应用[J]. 临床小儿外科杂志，2016, 15(1)：41-45.
41
Fukuda H, Mizobe M. Impact of nonadherence on complication risks and healthcare costs in patients newly-diagnosed with diabetes[J]. Diabetes Res Clin Pract, 2017，123：55-62.
42
De Geest S, Burkhalter H, Bogert L, et al. Describing the evolution of medication nonadherence from pretransplant until 3 years post-transplant and determining pretransplant medication nonadherence as risk factor for post-transplant nonadherence to immunosuppressives: the Swiss transplant cohort study[J]. Transpl Int, 2014，27(7)：657-666.
43
Hoegy D, Bleyzac N, Robinson P, et al. Medication adherence in pediatric transplantation and assessment methods: a systematic review[J]. Patient Prefer Adherence, 2019，13(7)：705-719.
44
宫月乔，付晓悦，郑桃花，等. 204例肝移植受者服药依从性单中心分析[J/CD]. 实用器官移植电子杂志，2019, 7(2)：90-94.
45
尚雅彬，刘红霞，王璐，等. 肝移植受者免疫抑制药物依从性现状调查及分析[J]. 中国护理管理，2017，17(4)：542-547.
46
Meng X, Gao W, Wang K, et al. Adherence to medical regimen after pediatric liver transplantation: a systematic review and meta-analysis[J]. Patient Prefer Adherence, 2018，17(13)：1-8.
47
Muduma G, Shupo FC, Dam S, et al. Patient survey to identify reasons for non-adherence and elicitation of quality of life concepts associated with immunosuppressant therapy in kidney transplant recipients[J]. Patient Prefer Adherence, 2016，12(10)：27-36.
48
Promraj R, Dumronggittigule W, Sirivatanauksorn Y, et al. Immunosuppressive medication adherence in liver transplant recipients[J]. Transplant Proc, 2016, 48(4)：1198-1201.
49
Shemesh E, Duncan S, Anand R, et al. Trajectory of adherence behavior in pediatric and adolescent liver transplant recipients: the medication adherence in children who had a liver transplant cohort[J]. Liver Transpl, 2018, 24(1)：80-88.
50
Killian MO, Schuman DL, Mayersohn GS, et al. Psychosocial predictors of medication non-adherence in pediatric organ transplantation: a systematic review[J]. Pediatr Transplant, 2018, 22(4)：e13188.
51
Hugon A, Roustit M, Lehmann A, et al. Influence of intention to adhere, beliefs and satisfaction about medicines on adherence in solid organ transplant recipients[J]. Transplantation, 2014，98(2)：222-228.
52
孙凯. 肝移植受者服药依从性现状及其影响因素分析[J]．中国现代普通外科进展，2014，17(5)：353-355.
53
Neuberger JM, Bechstein WO, Kuypers DR, et al. Practical recommendations for long-term management of modifiable risks in kidney and liver transplant recipients: a guidance report and clinical checklist by the Consensus on Managing Modifiable Risk in Transplantation (COMMIT) Group[J]. Transplantation, 2017，101(4S Suppl 2)：S1-S56.
54
Cassuto E, Pageaux GP, Cantarovich D, et al; OSIRIS investigators. Adherence to and acceptance of once-daily tacrolimus after kidney and liver transplant: results from OSIRIS, a French observational study[J]. Transplantation, 2016，100(10)：2099-2106.
55
Dobbels F, De Bleser L, Berben L, et al. Efficacy of a medication adherence enhancing intervention in transplantation: the MAESTRO-Tx trial[J]. J Heart Lung Transplant, 2017，36(5)：499-508.
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