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中华移植杂志(电子版) ›› 2023, Vol. 17 ›› Issue (01) : 32 -35. doi: 10.3877/cma.j.issn.1674-3903.2023.01.004

移植前沿

2022年肾移植领域研究进展
张修源1, 吕军好1, 陈大进1,()   
  1. 1. 310003 杭州,浙江大学医学院附属第一医院肾脏病中心
  • 收稿日期:2023-02-06 出版日期:2023-02-25
  • 通信作者: 陈大进

Research progress of kidney transplantation in 2022

Xiuyuan Zhang1, Junhao Lyu1, Dajin Chen1,()   

  1. 1. Kidney Disease Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
  • Received:2023-02-06 Published:2023-02-25
  • Corresponding author: Dajin Chen
引用本文:

张修源, 吕军好, 陈大进. 2022年肾移植领域研究进展[J]. 中华移植杂志(电子版), 2023, 17(01): 32-35.

Xiuyuan Zhang, Junhao Lyu, Dajin Chen. Research progress of kidney transplantation in 2022[J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(01): 32-35.

肾移植作为终末期慢性肾病患者的首选治疗方法,已让全球百余万尿毒症患者获得第二次生命。过去一年中全球在抗击新型冠状病毒疫情的同时,国内外同仁在肾移植诸多领域取得了相关进展。本文从供器官来源、新型冠状病毒感染对移植肾影响与防治、移植肾排斥反应、免疫耐受诱导以及再生医学等方面对2022年肾移植进展进行盘点概述。

Kidney transplantation, the preferred treatment for patients with end-stage renal disease, has given millions of uremic patients a second chance in life. In the past year, as the world fought against the COVID-19, excellent outcomes had been achieved in the field of kidney transplantation in China and abroad. This article summarizes advances and achievements in the field focusing on donor sources, the influence and prevention of COVID-19 on kidney transplantation, graft rejection, immunologic tolerance, regenerative medicine in 2022.

1
Aubert O, Yoo D, Zielinski D, et al. COVID-19 pandemic and worldwide organ transplantation: a population-based study[J]. Lancet Public Health, 2021, 6(10): e709-e719.
2
国务院应对新型冠状病毒肺炎疫情联防联控机制综合组. 关于对新型冠状病毒感染实施"乙类乙管"的总体方案[EB/OL]. (2022-12-07)[2023-01-05].

URL    
3
Peghin M, Grossi PA. COVID-19 positive donor for solid organ transplantation[J]. J Hepatol, 2022, 77(4): 1198-1204.
4
Bock MJ, Vaughn GR, Chau P, et al. Organ transplantation using COVID-19-positive deceased donors[J]. Am J Transplant, 2022, 22(9): 2203-2216.
5
Dhand A, Okumura K, Nabors C, et al. Solid organ transplantation from COVID positive donors in the United States: analysis of United Network for Organ Sharing Database[J]. Transpl Infect Dis, 2022: e13925.
6
国家卫生健康委办公厅,中央军委后勤保障部卫生局. 血站新冠病毒感染防控工作指引(第二版) [EB/OL]. (2022-12-17)[2023-01-05].

URL    
7
中华医学会器官移植学分会,中国医师协会器官移植医师分会,国家人体捐献器官获取质量控制中心. 新型冠状病毒感染者器官捐献专家共识[J]. 器官移植2023, 14(1): 1-10.
8
Brogan M, Ross MJ. COVID-19 and kidney disease[J]. Annu Rev Med, 2023, 74:1-13.
9
Pacheco ICR, Costa D, Sousa DS, et al. Kidney injury associated with COVID-19 infection and vaccine: a narrative review [J]. Front Med (Lausanne), 2022, 9: 956158.
10
Menez S, Parikh CR. COVID-19 and the kidney: recent advances and controversies[J]. Seminars in nephrology, 2022, 42(3): 151279.
11
Yang Y, Zou S, Xu G. An update on the interaction between COVID-19, vaccines, and diabetic kidney disease[J]. Front Immunol, 2022, 13: 999534.
12
Silva-Aguiar RP, Teixeira DE, Peres RaS, et al. Subclinical acute kidney injury in COVID-19: possible mechanisms and future perspectives[J]. Int J Mol Sci, 2022, 23(22): 14193.
13
Nogueira GM, Silva N, Moura AF, et al. Acute kidney injury and electrolyte disorders in COVID-19[J]. World J Virol, 2022, 11(5): 283-292.
14
Stein SR, Ramelli SC, Grazioli A, et al. SARS-CoV-2 infection and persistence in the human body and brain at autopsy[J]. Nature, 2022, 612(7941): 758-763.
15
Braun F, Lütgehetmann M, Pfefferle S, et al. SARS-CoV-2 renal tropism associates with acute kidney injury[J]. Lancet, 2020, 396(10251): 597-598.
16
Diao B, Wang C, Wang R, et al. Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection[J]. Nat Commun, 2021, 12(1): 2506.
17
Golmai P, Larsen CP, Devita MV, et al. Histopathologic and ultrastructural findings in postmortem kidney biopsy material in 12 patients with AKI and COVID-19[J]. J Am Soc Nephrol, 2020, 31(9): 1944-1947.
18
Sharma P, Uppal NN, Wanchoo R, et al. COVID-19-associated kidney injury: a case series of kidney biopsy findings[J]. J Am Soc Nephrol, 2020, 31(9): 1948-1958.
19
Wang L, Li X, Chen H, et al. Coronavirus disease 19 infection does not result in acute kidney injury: an analysis of 116 hospitalized patients from Wuhan, China[J]. Am J Nephrol, 2020, 51(5): 343-348.
20
Wang W, Xu Y, Gao R, et al. Detection of SARS-CoV-2 in different types of clinical specimens[J]. Jama, 2020, 323(18): 1843-1844.
21
林俊,丁小明,朱一辰,等. 肾移植受者新型冠状病毒疫苗接种建议[J] . 中华器官移植杂志2022, 43(2):67-73.
22
Li L, Chen X, Li B, et al. Effect of inactivated SARS-CoV-2 vaccine on thyroid function and autoimmunity within 28 days after the second dose [J]. Thyroid, 2022, 32(9): 1051-1058.
23
Xiong X, Wong CKH, Au ICH, et al. Safety of inactivated and mRNA COVID-19 vaccination among patients treated for hypothyroidism: a population-based cohort study[J]. Thyroid, 2022, 32(5): 505-514.
24
崔瑜,张雷,,吴建永. 肾移植抗体介导排斥反应的预防及诊疗要点[J]. 中华医学杂志2022, 102(26):2041-2044.
25
Ramalhete LM, Araújo R, Ferreira A, et al. Proteomics for biomarker discovery for diagnosis and prognosis of kidney transplantation rejection[J]. Proteomes, 2022, 10(3):24.
26
Nakorchevsky A, Hewel JA, Kurian SM, et al. Molecular mechanisms of chronic kidney transplant rejection via large-scale proteogenomic analysis of tissue biopsies[J]. J Am Soc Nephrol, 2010, 21(2): 362-373.
27
Lin XC, Sui WG, Qi SW, et al. Quantitative proteomic profiling of renal tissue in human chronic rejection biopsy samples after renal transplantation[J]. Transplant Proc, 2015, 47(2): 323-331.
28
Paşatu-Cornea AM, Ciciu E, Tuţǎ LA. Perforin: an intriguing protein in allograft rejection immunology (Review) [J]. Exp Ther Med, 2022, 24(2): 519.
29
Loga L, Dican L, Matei HV, et al. Relevant biomarkers of kidney allograft rejection[J]. J Med Life, 2022, 15(11): 1330-1333.
30
Dhrolia M, Ahmad A. Development of Banff Classification from 1991 to 2019 for identifying renal allograft rejection: a narrative review for nephrologists[J]. J Pak Med Assoc, 2022, 72(8):1615-1621.
31
Ho J, Rush DN, Krokhin O, et al. Elevated urinary matrix metalloproteinase-7 detects underlying renal allograft inflammation and injury[J]. Transplantation, 2016, 100(3): 648-654.
32
Heidari SS, Nafar M, Kalantari S, et al. Urinary epidermal growth factor is a novel biomarker for early diagnosis of antibody mediated kidney allograft rejection: a urinary proteomics analysis[J]. J Proteomics, 2021, 240: 104208.
33
Sui W, Huang L, Dai Y, et al. Proteomic profiling of renal allograft rejection in serum using magnetic bead-based sample fractionation and MALDI-TOF MS[J]. Clin Exp Med, 2010, 10(4): 259-268.
34
Yeo WS, Ng QX. Biomarkers of immune tolerance in kidney transplantation: an overview [J]. Pediatr Nephrol, 2022, 37(3): 489-498.
35
Braud C, Baeten D, Giral M, et al. Immunosuppressive drug-free operational immune tolerance in human kidney transplant recipients: Part I. Blood gene expression statistical analysis[J]. J Cell Biochem, 2008, 103(6): 1681-1692.
36
Brouard S, Mansfield E, Braud C, et al. Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance[J]. Proc Natl Acad Sci U S A, 2007, 104(39): 15448-15453.
37
Torrico S, Hotter G, Játiva S. Development of cell therapies for renal disease and regenerative medicine[J]. Int J Mol Sci, 2022, 23(24): 15943.
38
Bednar KJ, Lee JH, Ort T. Tregs in autoimmunity: Insights into intrinsic brake mechanism driving pathogenesis and immune homeostasis[J]. Front Immunol, 2022, 13: 932485.
39
Qu G, Chen J, Li Y, et al. Current status and perspectives of regulatory T cell-based therapy [J]. J Genet Genomics, 2022, 49(7): 599-611.
40
Petrosyan A, Montali F, Peloso A, et al. Regenerative medicine technologies applied to transplant medicine. An update [J]. Front Bioeng Biotechnol, 2022, 10: 1015628.
41
Matsuzaka Y, Yashiro R. Therapeutic strategy of mesenchymal-stem-cell-derived extracellular vesicles as regenerative medicine[J]. Int J Mol Sci, 2022, 23(12):6480.
42
García-Perdomo HA, Jurado-Penagos A. Application of regenerative medicine and 3d bioprinting in urology[J]. Actas urologicas espanolas, 2022, 46(6): 323-328.
43
Bejoy J, Qian ES, Woodard LE. Tissue culture models of AKI: from tubule cells to human kidney organoids[J]. J Am Soc Nephrol, 2022, 33(3): 487-501.
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