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中华移植杂志(电子版) ›› 2021, Vol. 15 ›› Issue (05) : 286 -290. doi: 10.3877/cma.j.issn.1674-3903.2021.05.006

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肾移植后人类细小病毒B19和BK病毒双重感染一例并文献复习
高霞1, 陈显凌2, 付军明1, 吴卫真1, 杨顺良1,()   
  1. 1. 350025 福州,中国人民解放军联勤保障部队第九〇〇医院泌尿外科
    2. 350001 福州,福建医科大学附属协和医院血液科
  • 收稿日期:2021-07-22 出版日期:2021-10-25
  • 通信作者: 杨顺良
  • 基金资助:
    福建省科技厅引导性项目(2015Y5007)

Diagnosis and therapy for dual infection of human parvovirus B19 and BK virus after renal transplantation and review of the literature

Xia Gao1, Xianling Chen2, Junming Fu1, Weizhen Wu1, Shunliang Yang1,()   

  1. 1. Department of Urology, 900th Hospital of Joint Logistics Support Force, Fuzhou 350025, China
    2. Department of Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China
  • Received:2021-07-22 Published:2021-10-25
  • Corresponding author: Shunliang Yang
引用本文:

高霞, 陈显凌, 付军明, 吴卫真, 杨顺良. 肾移植后人类细小病毒B19和BK病毒双重感染一例并文献复习[J]. 中华移植杂志(电子版), 2021, 15(05): 286-290.

Xia Gao, Xianling Chen, Junming Fu, Weizhen Wu, Shunliang Yang. Diagnosis and therapy for dual infection of human parvovirus B19 and BK virus after renal transplantation and review of the literature[J]. Chinese Journal of Transplantation(Electronic Edition), 2021, 15(05): 286-290.

图1 肾移植后HPV-B19和BKV双重感染受者IVIG治疗前后血红蛋白、肾功能与病毒载量动态变化情况注:HPV-B19.人类细小病毒B19; BKV.BK病毒;IVIG.静脉注射免疫球蛋白
表1 文献检索的HPV-B19感染肾移植受者临床资料[1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19]
项目 HPV-B19合并BKV感染组(n=11) 单纯HPV-B19感染组(n=129) HPV-B19感染病例(n=158)
性别(例,男/女/不详) 0/2/9 54/37/38 90/66/2
发病年龄(岁) 29~76 9~65 6~76
供肾类型(例,活体/尸体/不详) 0/3/8 41/38/50 79/65/14
多次移植(例,是/否/不详) 1/3/7 9/73/47 13/128/17
DGF(例,是/否/不详) 1/3/7 4/66/59 10/114/34
ATG或CD3单克隆抗体应用(例,是/否/不详) 2/1/8 16/37/76 24/46/88
CD25单克隆抗体应用(例,是/否/不详) 0/3/8 13/40/76 18/52/88
他克莫司(例,是/否/不详) 3/1/7 60/31/38 98/52/8
霉酚酸类药物(例,是/否/不详) 3/1/7 61/29/39 98/51/9
移植至HPV-B19感染发病时间(月) 0.5~ 3.0 0~98.0 0~98.0
最低血红蛋白(g/L) 65~81 26~89 24~90
白细胞减少(例,是/否/不详) 1/2/8 27/45/57 36/54/68
血小板减少(例,是/否/不详) 0/1/10 10/55/64 15/67/76
感染前发生排斥反应(例,是/否/不详) 2/1/8 19/46/64 43/86/29
应用IVIG(例,是/否/不详) 4/0/7 83/9/37 129/21/8
他克莫司转换为环孢素(例,是/否/不详) 0/2/9 14/55/60 21/73/64
停用抗代谢药物(例,是/否/不详) 0/3/8 32/39/58 38/50/70
降低免疫抑制强度(例,是/否/不详) 3/1/7 66/17/46 84/19/55
治疗后发生排斥反应(例,是/否/不详) 2/1/8 2/56/71 22/90/46
血红蛋白恢复(例,是/否/不详) 10/0/1 82/11/36 135/14/9
肾功能损伤(例,是/否/不详) 1/1/9 29/49/51 44/58/56
肾功能恢复(例,是/否/不详) 1/0/0 20/5/4 27/7/10
HPV-B19清除(例,是/否/不详) 2/1/8 38/17/74 49/22/87
移植术后HPV-B19感染复发(例,是/否/不详) 0/3/8 25/54/50 30/76/52
复发次数(次) - 1~ 9 1~ 9
复发时间(月) - 0.3~29.0 0.3~29.0
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