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中华移植杂志(电子版) ›› 2020, Vol. 14 ›› Issue (01) : 54 -57. doi: 10.3877/cma.j.issn.1674-3903.2020.01.014

所属专题: 文献

综述

MHC-Ⅰ链相关基因A介导的肾移植术后排斥反应研究进展
曾承1, 叶啟发1,()   
  1. 1. 430071 武汉大学中南医院肝胆疾病研究院 移植医学中心 移植医学技术湖北省重点实验室
  • 收稿日期:2019-08-01 出版日期:2020-02-25
  • 通信作者: 叶啟发
  • 基金资助:
    武汉大学医学腾飞计划平台建设项目(1606-600400017); 武汉大学自主科研项目(2042018kf0127); 湖北省自然科学基金面上类项目(2019CFB737)

The research progress of rejection associated with major histocompatibility complex class Ⅰ chain related gene A in kidney transplantation

Cheng Zeng1, Qifa Ye1,()   

  1. 1. Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University & Hubei Key Laboratory of Transplant Medical technology on Transplantation, Wuhan 430071, China
  • Received:2019-08-01 Published:2020-02-25
  • Corresponding author: Qifa Ye
  • About author:
    Corresponding author: Ye Qifa, Email:
引用本文:

曾承, 叶啟发. MHC-Ⅰ链相关基因A介导的肾移植术后排斥反应研究进展[J/OL]. 中华移植杂志(电子版), 2020, 14(01): 54-57.

Cheng Zeng, Qifa Ye. The research progress of rejection associated with major histocompatibility complex class Ⅰ chain related gene A in kidney transplantation[J/OL]. Chinese Journal of Transplantation(Electronic Edition), 2020, 14(01): 54-57.

肾移植是目前治疗终末期肾病最有效的方法,但移植术后并发排斥反应严重影响着受者预后,尤其是其导致的移植肾失功。肾移植术后排斥反应发生机制极其复杂,除经典HLA抗体外,近年来越来越多的学者注意到,MHC-Ⅰ链相关基因A(MICA)也在其中扮演着重要角色。本文综述MICA介导肾移植术后排斥反应的相关研究最新进展。

Kidney transplantation is the most effective treatment for end stage renal disease at present, but the rejection after kidney transplantation can seriously influence the prognosis, especially the renal allograft failure caused by rejection. The underlying mechanisms of rejection after kidney transplantation have not been clearly stated. Recently, besides HLA, many scholars have found that major histocompatibility complex class Ⅰ chain related gene A (MICA) also plays an important role leading to rejection. In this article, we reviewed the research progress of rejection after kidney transplantation which mediated by MICA.

1
Jorns C, Nowak G, Nemeth A, et al. De novo donor-specific HLA antibody formation in two patients with crigler-najjar syndrome type Ⅰ following human hepatocyte transplantation with partial hepatectomy preconditioning[J]. Am J Transplant, 2016, 16(3): 1021-1030.
2
Mizutani K, Terasaki P, Rosen A, et al. Serial ten-year follow-up of HLA and MICA antibody production prior to kidney graft failure[J]. Am J Transplant, 2005, 5(9): 2265-2272.
3
Mizutani K, Terasaki P, Bignon JD, et al. Association of kidney transplant failure and antibodies against MICA[J]. Hum Immunol, 2006, 67(9): 683-691.
4
Panigrahi A, Gupta N, Siddiqui JA, et al. Post transplant development of MICA and anti-HLA antibodies is associated with acute rejection episodes and renal allograft loss[J]. Hum Immunol, 2007, 68(5): 362-367.
5
Bahram S, Bresnahan M, Geraghty DE, et al. A second lineage of mammalian major histocompatibility complex class Ⅰ genes[J]. Proc Natl Acad Sci U S A, 1994, 91(14): 6259-6263.
6
Shiina T, Tamiya G, Oka A, et al. Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class Ⅰ region[J]. Proc Natl Acad Sci U S A, 1999, 96(23): 13282-13287.
7
Sawai H, Nishida N, Khor SS, et al. Genome-wide association study identified new susceptible genetic variants in HLA class Ⅰ region for hepatitis B virus-related hepatocellular carcinoma[J]. Sci Rep, 2018, 8:7958.
8
Wang WY, Wang F, Tian W. Identification of a novel MICB allele, MICB*030, by cloning and sequencing[J]. Int J Immunogenet, 2015, 42(4): 292-293.
9
Chen LC, Lan H, Sun L, et al. Genomic organization of the crested ibis MHC provides new insight into ancestral avian MHC structure[J]. Sci Rep, 2015, 5: 7963.
10
Zingoni A, Vulpis E, Cecere F, et al. MICA-129 dimorphism and soluble MICA are associated with the progression of multiple myeloma[J]. Front Immunol, 2018, 9: 926.
11
Bahram S, Spies T. The MIC gene family[J]. Res Immunol, 1996, 147(5): 328-333.
12
Yamakawa RH, Saito PK, Gelmini GF, et al. MICA diversity and linkage disequilibrium with HLA-B alleles in renal-transplant candidates in southern Brazil[J]. PLoS One, 2017, 12(4): e0176072.
13
Luo Q, Guo X, Peng S, et al. The association between MICA/MICB polymorphism and respiratory syncytial virus infection in children[J]. Int J Immunogenet, 2017, 44(6): 328-336.
14
Douik H, Ben Chaaben A, Attia Romdhane N, et al. Association of MICA-129 polymorphism with nasopharyngeal cancer risk in a Tunisian population[J]. Hum Immunol, 2009, 70(1): 45-48.
15
Sohn YH, Cha CH, Oh HB, et al. MICA polymorphisms and haplotypes with HLA-B and HLA-DRB1 in Koreans[J]. Tissue Antigens, 2010, 75(1): 48-55.
16
Hankey KG, Drachenberg CB, Papadimitriou JC, et al. MIC expression in renal and pancreatic allografts[J]. Transplantation, 2002, 73(2): 304-306.
17
Seiler M, Brabcova I, Viklicky O, et al. Heightened expression of the cytotoxicity receptor NKG2D correlates with acute and chronic nephropathy after kidney transplantation[J]. Am J Transplant, 2007, 7(2): 423-433.
18
Chauveau A, Tonnerre P, Pabois A, et al. Endothelial cell activation and proliferation modulate NKG2D activity by regulating MICA expression and shedding[J]. J Innate Immun, 2014, 6(1): 89-104.
19
Sumitran-Holgersson S, Wilczek HE, Holgersson J, et al. Identification of the nonclassical HLA molecules, mica, as targets for humoral immunity associated with irreversible rejection of kidney allografts[J]. Transplantation, 2002, 74(2): 268-277.
20
Togninalli M, Yoneoka D, Kolios AGA, et al. Pretransplant kinetics of anti-HLA antibodies in patients on the waiting list for kidney transplantation[J]. J Am Soc Nephrol, 2019, 30(11): 2262-2274.
21
Lougaris V, Patrizi O, Baronio M, et al. p85α is an intrinsic regulator of human natural killer cell effector functions[J]. J Allergy Clin Immunol, 2016, 138(2): 605-608.
22
Boukouaci W, Al-Daccak R, Dulphy N, et al. Soluble MICA-NKG2D interaction upregulates IFN-gamma production by activated CD3-CD56 NK cells: potential impact on chronic graft versus host disease[J]. Hum Immunol, 2013, 74(12): 1536-1541.
23
Croxatto D, Martini S, Chiossone L, et al. IL15 induces a potent antitumor activity in NK cells isolated from malignant pleural effusions and overcomes the inhibitory effect of pleural fluid[J]. Oncoimmunology, 2017, 6(4): e1293210.
24
Jin F, Lin H, Gao S, et al. The anti-tumor role of NK cells in vivo pre-activated and re-stimulated by interleukins in acute lymphoblastic leukemia[J]. Oncotarget, 2016, 7(48): 79187-79202.
25
Roberts AI, Lee L, Schwarz E, et al. NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment[J]. J Immunol, 2001, 167(10): 5527-5530.
26
Bauer S, Groh V, Wu J, et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA[J]. Science, 1999, 285(5428): 727-729.
27
Yu R, Xu S, Wang Y, et al. Role of MICA expression, anti-MICA antibodies and serum MICA during acute rejection in a rat-to-mouse cardiac transplantation model[J]. Int J Clin Exp Pathol, 2015, 8(11): 14514-14520.
28
Zhang Y, Stastny P. MICA antigens stimulate T cell proliferation and cell-mediated cytotoxicity[J]. Hum Immunol, 2006, 67(3): 215-222.
29
Zou Y, Mirbaha F, Lazaro A, et al. MICA is a target for complement-dependent cytotoxicity with mouse monoclonal antibodies and human alloantibodies[J]. Hum Immunol, 2002, 63(1): 30-39.
30
Wang S, Zhang C, Wang J, et al. Endothelial cells in antibody-mediated rejection of kidney transplantation: pathogenesis mechanisms and therapeutic implications[J]. J Immunol Res, 2017: 8746303.
31
Zou Y, Stastny P, Susal C, et al. Antibodies against MICA antigens and kidney-transplant rejection[J]. N Engl J Med, 2007, 357(13): 1293-1300.
32
Mizutani K, Terasaki PI, Shih RN, et al. Frequency of MIC antibody in rejected renal transplant patients without HLA antibody[J]. Hum Immunol, 2006, 67(3): 223-229.
33
Solgi G, Furst D, Mytilineos J, et al. Clinical relevance of pre and post-transplant immune markers in kidney allograft recipients: anti-HLA and MICA antibodies and serum levels of sCD30 and sMICA[J]. Transpl Immunol, 2012, 26(2-3): 81-87.
34
Seyhun Y, Ozdilli K, Oguz F, et al. Human leukocyte antigen and major histocompatibility complex class Ⅰ-related chain A antibodies after kidney transplantation in Turkish renal transplant recipients[J]. Transplant Proc, 2012, 44(6): 1660-1666.
35
Chaudhuri A, Ozawa M, Everly MJ, et al. The clinical impact of humoral immunity in pediatric renal transplantation[J]. J Am Soc Nephrol, 2013, 24(4): 655-664.
36
Zhang LW, Peng ZG, Xian WH, et al. Association of de novo human leukocyte antigen and major histocompatibility complex class Ⅰ chain-related gene-A antibodies and proteinuria with graft survival 5 years after renal transplantation[J]. Transplant Proc, 2013, 45(9): 3249-3253.
37
Terasaki PI, Ozawa M, Castro R. Four-year follow-up of a prospective trial of HLA and MICA antibodies on kidney graft survival[J]. Am J Transplant, 2007, 7(2): 408-415.
38
Ozawa M, Terasaki PI, Lee JH, et al. 14th International HLA and Immunogenetics Workshop: report on the prospective chronic rejection project[J]. Tissue Antigens, 2007, 69(Suppl 1): S174-S179.
39
Yao QC, Wang W, Li XB, et al. Expression characteristics of major histocompatibility complex class Ⅰ-related chain A antibodies and immunoadsorption effect in sensitized recipients of kidney transplantation[J]. Chin Med J (Engl), 2011, 124(5): 669-673.
40
Zhang M, Lu FM, Qu LX, et al. Serum major-histocompatibility-complex class Ⅰ-related chain A antibody detection for the evaluation of graft dysfunction in renal allograft recipients[J]. Chin Med J (Engl), 2011, 124(14): 2127-2131.
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