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中华移植杂志(电子版) ›› 2020, Vol. 14 ›› Issue (01) : 54 -57. doi: 10.3877/cma.j.issn.1674-3903.2020.01.014

所属专题: 文献

综述

MHC-Ⅰ链相关基因A介导的肾移植术后排斥反应研究进展
曾承1, 叶啟发1,()   
  1. 1. 430071 武汉大学中南医院肝胆疾病研究院 移植医学中心 移植医学技术湖北省重点实验室
  • 收稿日期:2019-08-01 出版日期:2020-02-25
  • 通信作者: 叶啟发
  • 基金资助:
    武汉大学医学腾飞计划平台建设项目(1606-600400017); 武汉大学自主科研项目(2042018kf0127); 湖北省自然科学基金面上类项目(2019CFB737)

The research progress of rejection associated with major histocompatibility complex class Ⅰ chain related gene A in kidney transplantation

Cheng Zeng1, Qifa Ye1,()   

  1. 1. Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University & Hubei Key Laboratory of Transplant Medical technology on Transplantation, Wuhan 430071, China
  • Received:2019-08-01 Published:2020-02-25
  • Corresponding author: Qifa Ye
  • About author:
    Corresponding author: Ye Qifa, Email:
引用本文:

曾承, 叶啟发. MHC-Ⅰ链相关基因A介导的肾移植术后排斥反应研究进展[J]. 中华移植杂志(电子版), 2020, 14(01): 54-57.

Cheng Zeng, Qifa Ye. The research progress of rejection associated with major histocompatibility complex class Ⅰ chain related gene A in kidney transplantation[J]. Chinese Journal of Transplantation(Electronic Edition), 2020, 14(01): 54-57.

肾移植是目前治疗终末期肾病最有效的方法,但移植术后并发排斥反应严重影响着受者预后,尤其是其导致的移植肾失功。肾移植术后排斥反应发生机制极其复杂,除经典HLA抗体外,近年来越来越多的学者注意到,MHC-Ⅰ链相关基因A(MICA)也在其中扮演着重要角色。本文综述MICA介导肾移植术后排斥反应的相关研究最新进展。

Kidney transplantation is the most effective treatment for end stage renal disease at present, but the rejection after kidney transplantation can seriously influence the prognosis, especially the renal allograft failure caused by rejection. The underlying mechanisms of rejection after kidney transplantation have not been clearly stated. Recently, besides HLA, many scholars have found that major histocompatibility complex class Ⅰ chain related gene A (MICA) also plays an important role leading to rejection. In this article, we reviewed the research progress of rejection after kidney transplantation which mediated by MICA.

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